标签： 杭州品茶工作室

In the "fruit world", grapefruit is a member who integrates face value, aroma and delicacy, and it definitely deserves a name.

However, not everyone can enjoy the delicious and beautiful grapefruit at any time. Maybe, it will sneak attack.

# The man’s muscles dissolved after eating grapefruit for seven days # Once boarded the hot search, and it was grapefruit that caused the man’s muscles to dissolve.

▲ Image source: Sina Weibo

However, this incident is not a "single crime" of grapefruit, but its "accomplice" is a drug called atorvastatin. Medicine is still a good medicine, grapefruit is still a good grapefruit, but after forced pairing, it becomes an invisible "killer" who hurts people.

Innocent, you must want to know:

Behind the scenes:

Furan coumarins

Then, why is this proud and wonderful fruit so angry?

"Behind the scenes" is a kind of component called furan coumarin.

Most drugs are metabolized mainly through the liver, because there is an enzyme in liver cells, which can promote the transformation of many drugs and thus promote the excretion of drugs from the body.

Many drugs will be metabolized by some enzymes in the intestine and liver when they enter the body, which is also called the first-pass effect.

However, this kind of coumarin in grapefruit can just inhibit the activity of drug enzymes in the intestine and liver of human body, thus increasing the absorption of drugs, slowing down or preventing the metabolism of drugs, and increasing the dosage of drugs in disguise.

There is a saying that drinking a glass of grapefruit juice while taking one tablet is sometimes equivalent to taking 20 tablets of this medicine.

In this way, a large number of pharmaceutical ingredients accumulate in the body, causing excessive efficacy, which will aggravate adverse reactions and even cause poisoning.

However, grapefruit, honey pomelo and sweet orange belong to citrus fruits with similar taste. Do other citrus fruits also have such "lethality"?

It depends on the content of furan coumarins in fruits.

Studies have determined that the content of furanocoumarin in the juice of many citrus fruits is the highest in grapefruit, Seville orange and Israeli green grapefruit, while the content in red pomelo, honey pomelo and golden pomelo is lower.

Stay away from grapefruit during medication.

Grapefruit is mainly easy to "attack" the human body in combination with the following drugs:

1, grapefruit+antihypertensive drugs = low blood pressure out of the lower limit.

Such drugs as nifedipine and verapamil. Grapefruit can increase the blood concentration of antihypertensive drugs, which is equivalent to invisibly increasing the dosage, so that the antihypertensive function of antihypertensive drugs is exerted too violently, so that the blood pressure drops again, which can cause dizziness, palpitation, fatigue, angina pectoris, myocardial infarction or stroke in severe cases.

2, grapefruit+lipid-lowering drugs = damage to the liver and muscles.

When taking statins, such as simvastatin, atorvastatin, lovastatin and other lipid-lowering drugs, stay away from grapefruit and grapefruit juice to avoid drug accumulation in the body and increase the risk of adverse reactions such as liver injury, muscle pain and rhabdomyolysis.

This "bad package" may also cause acute renal failure. Rosuvastatin, pravastatin, pitavastatin and fluvastatin were not affected by grapefruit.

3, grapefruit+antiallergic drugs = more prone to dizziness

If grapefruit is ingested during taking Terfenadine, Cismin and other antiallergic drugs, it may cause dizziness, palpitation, arrhythmia and other symptoms.

4, grapefruit+sleeping pills = make the side effects bigger.

Grapefruit can delay the metabolism of diazepam, midazolam and other sedative sleeping pills, and prolong the action time of the drugs, which will aggravate the symptoms of dizziness and drowsiness of the users.

Many patients may have dizziness and other symptoms the next day after taking the medicine, so drivers and people working at high altitude must pay special attention.

5, grapefruit+anti-anxiety/sedative = dizziness and lethargy

Some anti-anxiety drugs, such as diazepam and midazolam, can’t be taken with grapefruit, so as not to prolong the action time of the drugs, which will cause dizziness and drowsiness.

6, grapefruit+anti-rejection drugs = induced tumor

If cyclosporine and other anti-rejection drugs are taken together with grapefruit, it can lead to the increase of blood drug concentration, increase adverse reactions, increase liver and kidney toxicity, and even lead to the risk of tumor.

7, grapefruit+birth control pills = invalid

Although grapefruit can enhance the efficacy or toxicity of many drugs, it can reduce the activity of female contraceptives taken at the same time, which leads to contraceptive failure, because grapefruit can reduce the absorption of contraceptives.

Although the above influence has a great relationship with the consumption of grapefruit and grapefruit juice, everyone has different sensitivity to grapefruit. For the sake of life and health, in short, the safest way is:

No matter what medicine you are taking, cherish your life, stay away from grapefruit, and don’t even drink grapefruit juice!

However, the drama of "love each other and kill each other" between drugs and food is far more full of twists and turns than we thought. The following contraindications for drug use should be collected quickly! It is not too late to know!

▲ Image source: @ People’s Daily

Audit expert

sun jianguo

Doctor, researcher, doctoral supervisor of China Pharmaceutical University, majoring in pharmacokinetics.

He has been a visiting scholar in the School of Pharmacy of the University of Otago in New Zealand and the School of Pharmacy of the University of Washington in the United States, and was trained by the third echelon of the "333 High-level Talents Training Project" in Jiangsu Province. He has won a second prize of national scientific and technological progress and four first prizes of provincial scientific and technological progress.

He is a reviewer of clinical pharmaceutics, Xenobiotica, Pharmaceutical Progress and other magazines. He has presided over and completed four natural science foundations of Jiangsu Province, two national natural science foundations and one national key research and development plan, presided over and participated in several sub-projects of major national scientific research projects. In recent years, he has published more than 20 papers (including 15 SCI papers) by the first author or correspondent, and granted 3 patents.

Cooperate with enterprises to obtain 5 clinical approvals of new drugs, and be responsible for completing pharmacokinetic studies to support enterprises to obtain multiple certificates of new drugs.

-Produced by the editorial department of "I wish you health" of Jiangsu Phoenix Science and Technology Publishing House-

Chief planner: Wang Yao and Dong Ling

Original title: "Never eat this fruit during taking medicine! Not only will it lose its efficacy, but it will be fatal in serious cases! 》

Read the original text

　　BEIJING, Dec. 26 (Reporter Cheng Chunyu, Li Jinlei, Zhong Qing Wu Tao) Recently, the National Development and Reform Commission, the Ministry of Housing and Urban-Rural Development, the Ministry of Commerce, the Ministry of Industry and Information Technology, the Ministry of Communications and other ministries and commissions held intensive annual work meetings to implement the spirit of the Central Economic Work Conference, deploy key tasks in 2018, and frequently distribute lists of people’s livelihood. Your purse will be affected by these policies in 2018.

　　Data Map: The picture shows a corner of Chengdu, and the sun is rising in the east. China News Service reporter Liu Zhongjun photo

　　The property market will be so regulated! Meet the first set of just-needed, support and improvement needs next year.

　　On December 23, Wang Menghui, Minister of Housing and Urban-Rural Development, said at the National Conference on Housing and Urban-Rural Development that next year, differentiated control policies will be implemented for all kinds of needs to meet the first set of needs, support the improvement of demand and curb speculative real estate speculation.

　　Yan Yuejin, research director of the think tank center of Yiju Research Institute, predicts that the policy of satisfying the first set of just-needed orientation and supporting improved demand may be slightly relaxed, and the identification of the first suite and the second suite, the division of ordinary housing and non-ordinary housing and other aspects will not be ruled out. The possibility of fine-tuning the policy.

　　Xie Yifeng, president of China Urban Real Estate Research Institute, thinks that some second, third and fourth tier cities may have fine-tuned policies. "For example, cancel the first set of social security and tax payment years that are just needed for non-household registration, and allow non-local household registration population to purchase a second set of improved housing; Reduce the down payment ratio of the first suite and the second suite; Lower the interest rate of housing credit; Increase the tax reduction and exemption of just-needed and improved housing demand. "

　　2Since December 1, 2017, the import tariffs on 187 consumer goods such as special formula infant milk powder have been reduced centrally. Luo Yunfei

　　"Hands-on Party" welfare! Import tariffs on some products will be lowered.

　　On December 25th, the National Business Work Conference was held. Chen Guokai, director of the Market Operation Department of the Ministry of Commerce, said that the government will develop tax-free business, study and further improve the tax-free policy, and provide more convenient shopping options for people entering and leaving the country. At the same time, large-scale e-commerce platforms are encouraged to cooperate with internationally renowned brands to introduce foreign high-quality goods and services to meet the high-end consumer demand.

　　Since December 1, 2017, China has reduced the import tariffs on 187 consumer goods, such as infant formula, seal oil and anticancer drugs, and the average tax rate has dropped from 17.3% to 7.7%. In the future, tariffs on more products will be lowered. The reporter noted that the Central Economic Work Conference held a few days ago proposed to actively expand imports and reduce import tariffs on some products next year.

　　From the outside world, with the implementation of these measures, consumers can enjoy cheap goods and services from abroad more conveniently and cheaply at home.

　　The picture shows Sujiahang Suzhou City toll station vehicles queuing at the station. Wang Sizhe

　　There are discounts on taking the expressway! The pilot project of time-sharing differential toll collection on expressways should be expanded.

　　The Ministry of Communications held a national conference on transportation work on the 25th, proposing that in 2018, it is necessary to further reduce costs and accelerate the construction of logistics corridors and integrated freight hubs (logistics parks). We will steadily expand the pilot project of differentiated toll collection for expressways in different time periods. Consolidate the results of various fines, inspections and clean-up of enterprise-related charges in the transportation field.

　　The previous Central Economic Work Conference also proposed to continue to clean up the fees charged by enterprises, intensify the investigation and rectification of arbitrary charges, deepen the reform of power, oil and gas, railways and other industries, and reduce energy consumption and logistics costs.

　　In 2017, the Ministry of Communications organized Shanxi, Zhejiang, Hunan and other provinces to carry out pilot projects for differentiated toll collection by time. The government basically canceled the second-class highway charges for repayment of loans, and implemented a number of measures such as road green passage and differentiated charges, which reduced the logistics cost by more than 88 billion yuan this year. Experts believe that the differentiated charging policy effectively balances the spatial distribution of the road network, improves the efficiency and benefit of the expressway road network, and the effect of reducing costs and increasing efficiency will be more obvious.

　　The picture shows the local people experiencing the 4G network in a mobile business hall in Taiyuan, Shanxi. China News Agency issued Wei Liang photo

　　Speed up and reduce fees "without stopping"! The average tariff of mobile traffic will drop again.

　　The Ministry of Industry and Information Technology held a national industrial and information work conference on the 25th, pointing out that it is necessary to increase the speed and cost reduction of the network next year. Accelerate the popularization of 100 Mbps broadband, promote the construction of gigabit cities, achieve comprehensive coverage of urban and rural areas with high-speed fiber-optic broadband networks, further improve the coverage and rate of 4G networks, further reduce the average tariff of mobile traffic, and further reduce the use cost of broadband and private lines for small and medium-sized enterprises.

　　The reporter noted that the National Conference on Industry and Informatization has deployed "speeding up and reducing fees" as its work content for many years. In 2017, the domestic long-distance and roaming charges for mobile phones were completely abolished, and the private line charges for small and medium-sized enterprises were greatly reduced. The international long-distance telephone charges dropped by more than 90%, and the average charges for mobile Internet traffic dropped to 26 yuan /GB, with more than 80% of fiber-optic broadband users and 60% of users with access bandwidth exceeding 50M.

　　For some popular demand hotspots in 2017, the meeting has been deployed — — Study and formulate a national promotion plan for number portability; Continue to promote the management of spam messages, harassing calls and false numbers. We will further prevent and crack down on communication information fraud, manage the interception system well, and actively study and deal with new problems such as online fraud.

　　Data map: Xiangxi villagers who stayed in the new house showed a happy smile. Photo by Tang Xiaoqing

　　Agriculture, rural areas and farmers are welcome! Development and Reform Commission: Scientifically Formulating the National Rural Revitalization Strategic Plan

　　From December 22nd to 23rd, the National Development and Reform Work Conference was held. The meeting studied and deployed the main tasks and key tasks of development and reform in 2018, including implementing major measures of rural revitalization strategy, scientifically formulating national rural revitalization strategic plan, building modern agricultural industrial system, production system and management system, ensuring national food security and building beautiful and livable villages.

　　The Central Economic Work Conference held recently proposed to improve the system and mechanism of urban-rural integration development and remove various obstacles that hinder the elements from going to the countryside. We will promote the structural reform of the supply side of agriculture, adhere to the principle of promoting agriculture by quality and green, and shift the agricultural policy from increasing production to improving quality.

　　Wei Houkai, director of the Institute of Rural Development of China Academy of Social Sciences, said that affluent life is an important symbol of rural revitalization. In the next step, farmers should rely more on agriculture, rural areas and rural industries to establish a long-term mechanism to increase their income. (End)

　　An assessment report released by Israel’s Ministry of Economy and Industry earlier this week shows that the new round of Palestinian-Israeli conflict has seriously impacted Israel’s national economy. Nearly one-fifth of the country’s labor force and the vast majority of Palestinians with work permits are out of work, resulting in economic losses of 13 billion new shekels (about 3.44 billion US dollars).

△ On November 15th, local time, Israeli air strikes were carried out in northern Gaza.

　　On October 7th, the Palestinian Islamic Resistance Movement (Hamas) launched a surprise attack on military and civilian targets in Israel from the Gaza Strip, and Israeli Prime Minister Benjamin Netanyahu declared the whole country into a "state of war" on the same day. Over the past month or so, Israeli military operations in the Gaza have killed more than 11,000 Palestinians and injured more than 28,000 others. About 1,200 people in Israel died in the conflict and more than 7,200 people were injured. Another 240 people were held hostage by armed groups in Gaza, such as Hamas. Hamas said that dozens of them were killed by Israeli air strikes.

　　According to the assessment report released by the Israeli Ministry of Economy and Industry on the 13th, about 764,000 domestic laborers have been out of work since the outbreak of this round of conflict, accounting for 19.4%. The main reasons for the absence of domestic labor force include being drafted into the Israeli army reserve, high risk in residential areas, and having to accompany their children at home because of the suspension of school. In response to the war, the Israeli government announced the mobilization of 360,000 reservists.

　　The report pointed out that after the conflict broke out, 97% of the approximately 135,000 Palestinian laborers working in Israel were not allowed to enter Israel at this stage, which led to the impact on many important industries such as construction, agriculture and service. Most of these Palestinian laborers come from the West Bank, and many from Gaza. The economic loss caused by the inability of Palestinian workers to be on duty is about 3 billion NIS (US$ 780 million), and the economic loss caused by the absence of all workers has reached 13 billion NIS.

△ November 14th, local time, a refugee camp in Gaza.

　　According to this report, due to the conflict, the demand for goods and services in Israel’s domestic market has declined, and household credit card spending has dropped by about 20% year-on-year.

　　According to data from Israel’s Central Bureau of Statistics, since the conflict broke out, more than half of Israeli enterprises have faced more than 50% turnover losses. In southern Israel, near the Gaza Strip, two-thirds of enterprises either closed down or operated minimally. In addition, the data shows that from October 8 to October 31, the number of foreign tourists arriving in Israel decreased by 73.1% compared with the same period of last year, and the number of people going abroad in Israel decreased by 45.1% year-on-year.

　　According to the report released by Israel Airport Authority on 14th, there are only seven foreign airlines flying to Israel. The passenger flow of Ben-Gurion International Airport, Israel’s largest airport, was 1.17 million in October, a decrease of 41.25% compared with the same period in 2022; There were 9078 international flights, down 28.9% year-on-year.

　　Israel’s National Security Institute estimates that since the outbreak of the conflict, the average daily expenditure of the Israeli government has been about 1 billion new shekels (about 260 million US dollars), and it is estimated that the total cost of Israel in this round of conflict will reach 150 billion to 200 billion new shekels, accounting for about 10% of GDP.

Feature: Picture Channel

　　On June 3, Wu Mengda, a Hong Kong artist, was welcomed by the children of Hongbai Town Primary School in Shifang City, the hardest-hit area of Sichuan Province. Hongbai Town in Shifang City suffered heavy losses in the "May 12" earthquake. Photo by China News Agency

　　Taiwan diva Xu Ruo?, Hong Kong veteran actor Wu Mengda, who stars in the Chinese-Korean romantic comedy "The Art of Love and War", recently appeared on Hunan Satellite TV’s "The Story Behind". Wu Mengda looked back on the years when he was "hurt by women, drinking and gambling" like a review, and revealed that he almost committed suicide when he went bankrupt due to 300,000’s debts.

　　And Xu Ruo? talks generously about the experience of many years of love, and laughs that she likes to use the "hard-to-get" trick in the "36 Love Strategies".

　　[Career Peak] "Hu Tiehua" lost herself

　　In 1971, Wu Mengda, a young man under the age of 20, thought he was a handsome guy who could eat well in the entertainment industry and excitedly went to the TVB artist training class. After performing a mime, he became classmates with Zhou Yun-fat and Zhou Xingchi. "When I was playing tricks, I only had 8 lines a day at most, such as’Master is not well, Madam is sick ‘, and I could enjoy it for a while."

　　At that time, it was the golden age of Hong Kong movies, and with his cleverness, Wu Mengda established a firm foothold in the circle. Hu Tiehua, who took on the role in "The Legend of Chu Liuxiang", brought his career to the peak, earning 1,500 US dollars in one appearance. "Many people around me held me up to the sky. I completely lost myself. I drank and played cards every day. I didn’t have the heart to work, so I looked forward to finishing work early."

　　[Encountered difficulties] I hated Zhou Yunfa very much at that time

　　In 1980, Wu Mengda suddenly found that the unemployment crisis was approaching, and he not only could not make ends meet, but also owed 300,000 Hong Kong dollars in gambling debts. What was more uncomfortable was that there was no drama to play, and in this case he was suddenly declared bankrupt.

　　In order to get through this difficult time, the first thing he thought of was his best friend Chow Yun-fat. "I didn’t expect him to say to me, ‘You solve it yourself!’ I hated him so much at the time, I couldn’t understand that sentence, 300,000 what is it to him? I thought about it at home for three days. I remembered a reservoir I went to play with when I was a child, and everything was solved by jumping down. I wanted to commit suicide." Not only Chow Yun-fat of the same generation, but also his junior brother Du Qifeng "also thought I was a piece of mud and looked down on me." Speaking of these unbearable memories, and seeing his condescending role in "Shaolin Football" on the screen, Uncle Da couldn’t help but wipe his tears.

　　[Reinvigorated] "Stephen Chow + Wu Mengda" has become a classic

　　In 1988, he started his first collaboration with Stephen Chow on "He’s From the Jianghu", and since then the "Stephen Chow + Wu Mengda" model has become a symbol of the nonsense style.

　　However, the close cooperation between each other caused a crack in the film "Kung Fu". "When I encountered’SARS ‘, my schedule was up, and I couldn’t make’Kung Fu’. He didn’t think I was enough friends." Regarding the relationship between the two, Wu Mengda bluntly said that Zhou Xingchi now feels different from before. "He has raised himself to a high level, and now no one dares to deny him, but I think he needs to be denied, because he is a mortal, and everyone is wrong sometimes."

　　Wu Mengda also said that no matter what the outside world thinks of Zhou Xingchi, the other party is undoubtedly talented. "Like’Journey to the West ‘, he just wants to make it good and fun, and he didn’t consider it a classic at all." Special Reporter | Wang Lu | Wen

Editor in charge: Wang Jiaolong

Original title: On May Day, the video of A Xin’s live jumping subject III was shocked and exposed, showing his love and passion for music.

Hey, friends, have you paid attention to the New Year’s concert on May Day recently? At the "Back to that Day" concert in Taichung, lead singer A Xin performed a stunning video of dance subject III, which was really shocking! The difficulty coefficient of this dance is very high, which is beyond the control of ordinary dancers. When A Xin dances this dance, we can really feel his love for music and passionate attitude. His dance steps are smooth and natural, and every movement is full of strength and rhythm, which makes people excited. This performance once again proves Mayday’s strength and good stage charm. Let’s look forward to their wonderful performance in the future!

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