On New Year’s Day holiday, the national tourism market is stable and short-distance, and Zhou Bianyou drives consumption fever

CCTV News:According to the statistics of the data center of the Ministry of Culture and Tourism, during the New Year’s Day holiday this year, the national tourism market took short trips and the city of Zhou Bianyou as the main travel directions. While doing a good job in epidemic prevention and control, scenic spots around the country have carried out a series of theme activities to let tourists welcome the New Year in a rich experience.

With the approach of the Beijing Winter Olympics, there has been an upsurge of national winter sports in various places. At the intangible cultural heritage market in Huaxi District, Guiyang City, 20 Miao Xiu inheritors of Huaxi and 30 teenagers from urban areas embroidered a 10-meter scroll with the theme of "Beautiful Huaxi welcomes the Winter Olympics, and Miao Xiu adds a chapter to it", which passed on the traditional skills from generation to generation.

Wang Qiping, national inheritor of Huaxi Miao Xiu, Guiyang City, Guizhou Province:From ancient times to the present, the colors used are red, white background, white line, red, yellow and green. This gray is from deep to light, which is particularly beautiful with this color.

Gu Weiwei, the municipal inheritor of Huaxi Miao Xiu, Guiyang City, Guizhou Province:We embroidered a 10-meter scroll with the intangible skill of Huaxi Miao Xiu to cheer for the coming Beijing Winter Olympics.

Under the strict implementation of epidemic prevention and control requirements, the snow sculpture Group with the theme of "Passion for Winter Olympics" created by 18 local forestry workers in Yichun Ice and Snow Wenchuang Garden, Heilongjiang Province, was magnificent. Tourists from inside and outside the province were attracted by the unique ice sculpture snow sculpture and took out their mobile phones to take photos as a souvenir.

Tourist Li Wei:I like this landscape very much and help our Winter Olympics.

The Ministry of Culture and Tourism reminds tourists to inquire about the opening of tourist attractions and ticket reservation measures in advance before departure, and plan the tourist routes and time reasonably. Try to avoid popular scenic spots and peak travel hours, and do not travel to the cities where medium and high-risk areas are located.

Never eat this fruit during taking medicine, which will not only lose its efficacy, but also be fatal.

In the "fruit world", grapefruit is a member who integrates face value, aroma and delicacy, and it definitely deserves a name.

However, not everyone can enjoy the delicious and beautiful grapefruit at any time. Maybe, it will sneak attack.

# The man’s muscles dissolved after eating grapefruit for seven days # Once boarded the hot search, and it was grapefruit that caused the man’s muscles to dissolve.

▲ Image source: Sina Weibo

However, this incident is not a "single crime" of grapefruit, but its "accomplice" is a drug called atorvastatin. Medicine is still a good medicine, grapefruit is still a good grapefruit, but after forced pairing, it becomes an invisible "killer" who hurts people.

Innocent, you must want to know:

Behind the scenes:

Furan coumarins

Then, why is this proud and wonderful fruit so angry?

"Behind the scenes" is a kind of component called furan coumarin.

Most drugs are metabolized mainly through the liver, because there is an enzyme in liver cells, which can promote the transformation of many drugs and thus promote the excretion of drugs from the body.

Many drugs will be metabolized by some enzymes in the intestine and liver when they enter the body, which is also called the first-pass effect.

However, this kind of coumarin in grapefruit can just inhibit the activity of drug enzymes in the intestine and liver of human body, thus increasing the absorption of drugs, slowing down or preventing the metabolism of drugs, and increasing the dosage of drugs in disguise.

There is a saying that drinking a glass of grapefruit juice while taking one tablet is sometimes equivalent to taking 20 tablets of this medicine.

In this way, a large number of pharmaceutical ingredients accumulate in the body, causing excessive efficacy, which will aggravate adverse reactions and even cause poisoning.

However, grapefruit, honey pomelo and sweet orange belong to citrus fruits with similar taste. Do other citrus fruits also have such "lethality"?

It depends on the content of furan coumarins in fruits.

Studies have determined that the content of furanocoumarin in the juice of many citrus fruits is the highest in grapefruit, Seville orange and Israeli green grapefruit, while the content in red pomelo, honey pomelo and golden pomelo is lower.

Stay away from grapefruit during medication.

Grapefruit is mainly easy to "attack" the human body in combination with the following drugs:

1, grapefruit+antihypertensive drugs = low blood pressure out of the lower limit.

Such drugs as nifedipine and verapamil. Grapefruit can increase the blood concentration of antihypertensive drugs, which is equivalent to invisibly increasing the dosage, so that the antihypertensive function of antihypertensive drugs is exerted too violently, so that the blood pressure drops again, which can cause dizziness, palpitation, fatigue, angina pectoris, myocardial infarction or stroke in severe cases.

2, grapefruit+lipid-lowering drugs = damage to the liver and muscles.

When taking statins, such as simvastatin, atorvastatin, lovastatin and other lipid-lowering drugs, stay away from grapefruit and grapefruit juice to avoid drug accumulation in the body and increase the risk of adverse reactions such as liver injury, muscle pain and rhabdomyolysis.

This "bad package" may also cause acute renal failure. Rosuvastatin, pravastatin, pitavastatin and fluvastatin were not affected by grapefruit.

3, grapefruit+antiallergic drugs = more prone to dizziness

If grapefruit is ingested during taking Terfenadine, Cismin and other antiallergic drugs, it may cause dizziness, palpitation, arrhythmia and other symptoms.

4, grapefruit+sleeping pills = make the side effects bigger.

Grapefruit can delay the metabolism of diazepam, midazolam and other sedative sleeping pills, and prolong the action time of the drugs, which will aggravate the symptoms of dizziness and drowsiness of the users.

Many patients may have dizziness and other symptoms the next day after taking the medicine, so drivers and people working at high altitude must pay special attention.

5, grapefruit+anti-anxiety/sedative = dizziness and lethargy

Some anti-anxiety drugs, such as diazepam and midazolam, can’t be taken with grapefruit, so as not to prolong the action time of the drugs, which will cause dizziness and drowsiness.

6, grapefruit+anti-rejection drugs = induced tumor

If cyclosporine and other anti-rejection drugs are taken together with grapefruit, it can lead to the increase of blood drug concentration, increase adverse reactions, increase liver and kidney toxicity, and even lead to the risk of tumor.

7, grapefruit+birth control pills = invalid

Although grapefruit can enhance the efficacy or toxicity of many drugs, it can reduce the activity of female contraceptives taken at the same time, which leads to contraceptive failure, because grapefruit can reduce the absorption of contraceptives.

Although the above influence has a great relationship with the consumption of grapefruit and grapefruit juice, everyone has different sensitivity to grapefruit. For the sake of life and health, in short, the safest way is:

No matter what medicine you are taking, cherish your life, stay away from grapefruit, and don’t even drink grapefruit juice!

However, the drama of "love each other and kill each other" between drugs and food is far more full of twists and turns than we thought. The following contraindications for drug use should be collected quickly! It is not too late to know!

▲ Image source: @ People’s Daily

Audit expert

sun jianguo

Doctor, researcher, doctoral supervisor of China Pharmaceutical University, majoring in pharmacokinetics.

He has been a visiting scholar in the School of Pharmacy of the University of Otago in New Zealand and the School of Pharmacy of the University of Washington in the United States, and was trained by the third echelon of the "333 High-level Talents Training Project" in Jiangsu Province. He has won a second prize of national scientific and technological progress and four first prizes of provincial scientific and technological progress.

He is a reviewer of clinical pharmaceutics, Xenobiotica, Pharmaceutical Progress and other magazines. He has presided over and completed four natural science foundations of Jiangsu Province, two national natural science foundations and one national key research and development plan, presided over and participated in several sub-projects of major national scientific research projects. In recent years, he has published more than 20 papers (including 15 SCI papers) by the first author or correspondent, and granted 3 patents.

Cooperate with enterprises to obtain 5 clinical approvals of new drugs, and be responsible for completing pharmacokinetic studies to support enterprises to obtain multiple certificates of new drugs.

-Produced by the editorial department of "I wish you health" of Jiangsu Phoenix Science and Technology Publishing House-

Chief planner: Wang Yao and Dong Ling

Original title: "Never eat this fruit during taking medicine! Not only will it lose its efficacy, but it will be fatal in serious cases! 》

Read the original text

May net text list | Martial arts is not that martial arts.

[Editor’s note]Through the superficial phenomenon of "little white" in online literature, many works with equal emphasis on entertainment and ideology have been born. This book list will introduce a more diverse online world, from the unpopular to the popular, from the small crowd to the public, and those outstanding works of various types.

"The Legend of Cyberhero" by My Taoist Master is not alone.

Cyberpunk’s martial arts essays, which have a good reputation, are very tasty.

The author’s new book, Walking into Cultivating Immortals, is probably equivalent to gunnm+ghost in the shell.

The novel’s brain is wide open, with programming ability as the martial arts framework, using programming and hacking techniques to fight, which leads to the concept of cybermartial arts. The fighting description is vivid, energetic, strange and tense, and it is integrated into dystopia, doomsday wasteland, chivalrous spirit and other elements. At the beginning, the protagonist has only one head, which was picked up in the garbage dump and lost his memory. After fighting again and again, he gradually recovered those things deep in his memory.

The most impressive thing is the creation of the cyber atmosphere. It can be said that it is not generally excellent. A simple outline depicts an absurd and desperate cyber society. The ruling class is absurd and cruel, and people are spoiled by animals, and even babies are transformed into speakers and locators to play with sympathetic slaves. The bottom cyber people (transformed people) are numb and struggling hard, and the feeling of darkness and absurdity is really unspeakable. The full text is gloomy and solemn, magnificent, vivid, bloody and thought-provoking! The dark and absurd cyber atmosphere is quite brilliant, but it is precisely because of the heavy and gloomy novel theme that it is difficult for book lovers who are used to relaxed, happy and cool writing style to accept.

Recommended index, 4.5 stars. I recommend it to the party that is mentally prepared and tired of reading mainstream online routines. If you want to experience a cyber style, this book is very suitable, but it needs a little patience. In a way, this fairy grass!

"self-help strategy of salted fish" by seems to be a master

Urban rebirth from media entrepreneurship.

The author is an old writer of DND western fantasy games more than ten years ago, who seems to be a master, and has written the classic "Mysterious Badge of Forgotten Country". This time, it is the return of missing people, and it is an urban text.

Different from the rebirth of commercial warfare, this book is a contemporary parallel to time and space, and the time point is the present. The main line is self-media entrepreneurship that keeps up with the trend of the times, and it is integrated into the author’s entrepreneurial experience for more than ten years. Therefore, the entrepreneurial part is particularly wonderful, and the convenience store+bike-sharing+community modularization is really carefully pondered, and the writing goes without saying. The old author has accumulated experience, not to mention doubt.

For me, the biggest highlight of the novel is that the author’s commercial dry goods make people shine at the moment, and he has a deep understanding of media operation, and he knows about start-ups and various commercial operations. The plot follows the hot spots closely, so Tik Tok users should be very kind to read this book! However, it should be noted that the emotional drama about the first love is very general, and the ex-girlfriend is lingering, which has caused a lot of controversy.

The recommendation index, 3.5 stars, is recommended to dry goods party readers who like to read novels and learn something.

"The Wonderful Adventure of Li Qing" by Wang of the River

High-quality JOJO fans with rare male frequency hardcore wits actually attacked by word of mouth after finishing this book? ! !

With the skills of a blind monk, the protagonist went to Italy in JOJO world. At the beginning of Jojo 5, he paid attention to the rational development of existing abilities to defeat the enemy, focusing on wits. The use of abilities can be said to be an open mind, and he wrote the shining golden spirit of the original book, "Overcoming death and despair with courage and wisdom". Every battle was online, which restored the stagnation of the original commentary. The plot was compact, the fighting continued, and the style of writing was sophisticated. For Jojo fans,

The most amazing thing about the novel is that after the book was finished, the novel ushered in a word-of-mouth counterattack, and all the book lovers who criticized the book at the beginning turned into the real fragrant party. Why?

Because the grey line of grass snake and the pulse are thousands of miles, the layout begins from the beginning to the final end, revealing the mystery and the foreshadowing laid in the previous article, which is very surprising and carefree, and it is really commendable in the online world.

However, I still want to emphasize that although this book is very worth reading for Chef JO, the limitations of the minority works are also worth mentioning. The opening of the novel is long and repetitive, and it is obvious that the above-mentioned Zhenxiang Party left a message and spit out bad reviews at this time. Although it was well received after reading it, there was something wrong with the opening, and then there was the rhythm of the story, especially the battle after battle, which led to a serious lack of refreshment. However, when reading it, it was hard to let go. Another problem is that it is too similar to the expression of comics, which challenges readers’ imagination and brain tonic ability. If you don’t have a certain understanding of JOJO, you will be fascinated.

Recommended index, 3.5 stars. If you like JOJO, the recommendation index of that book is five stars.

Knife cage by insect dream

The unique martial arts style Xianxia literature combining martial arts and Taoism.

At the beginning, it is very chivalrous, with the leading character in troubled times, Dreadwind, a lone star, who is like a fire. At the beginning, he is dressed in Yamaraja’s knife, telling everyone that it feels like Tsui Hark’s movie "Knife". In troubled times, bandits and bandits abound, and there are strange and monitors above the common customs. That smell makes people want to stop. It’s a bit like chasing Yang Shen.

Generally speaking, the opening of the novel is as always, and the description of the fighting is still enjoyable. Some book lovers think that the description of the fighting is as pure as fire. It is comparable to a bird (the evaluation is a bit high), and the setting system can be justified. The disadvantage is that the writing is obscure and the main line is not clearly explained. Readers who read ten lines easily get confused.

The recommended index is three stars. It should be noted that this author’s consistent shortcoming is that he pulls his hips in the middle and late period, and his writing skills are very energetic, and he will be in chaos when he arrives in the fairy. I hope you can hit me in the face this time.

"The Green Dragon Nests" by Gui Xi Bei Ming

DND becomes a stream of dragons and animals, a niche boutique.

It tells the story of the indigenous green dragon nesting. After leaving his mother, the young green dragon, who was blessed by five dragons, took the maid mage and set foot on the road of nesting, subduing evil tribes along the way, venturing to farm and competing for treasures. There are quite a few such dragon-changing books, but most of them are written by human psychological behavior. This author is rare, and his writing style is sophisticated, and his story is based on the characteristics of dragon’s thinking mode, and his portrayal of non-human beings can be vivid and flesh-and-blood! Abundant details pave the way, which makes people feel very substituted.

Two days ago, I saw Ma Boyong recommend this book in Weibo. Let me quote the comments of the prince:

"The Green Dragon’s Nest-building" should be the best DND streaming novel I have ever read after Memo of Spirit Absorbing Monsters and Ghost (formerly I am embarrassed to mention it …). Against the background of Phelan mainland, a green dragon leaving its nest is determined to start its own nest and career. At first glance, it’s a fantasy farming with a slightly cheap and funny style, but what’s hidden under it is the deep tactical wisdom. For example, in the first big plot, the dwarf steals the heart of the mountain. I just expected a wonderful war between the two sides. I didn’t expect every turn to be unexpected. It can be said that none of the participants are fools, intrigued with each other and brilliant, which completely exceeds the stereotype of traditional Phelan race. In addition, the author’s description of the dragon’s mentality is so meticulous that he almost doubts whether it is the reincarnation of the dragon. (@ Magic’s Essence is written so well because he is himself) ".

Recommended index, four stars. It should be noted that the update is slow.

"Little people in the Jianghu" by drying up and dispersing people

A rare martial arts quick-wear article with cologne flavor.

This is an author who focuses on martial arts fans. His writing style is not bad, and the description of fighting is above the standard. This book is the story of martial arts astronomy with the main flavor of Gu Long, and the story of the protagonist’s crossing in various Gu Long novels. The growth of the original protagonist is also well described. The first copy of "Big Man", the second copy of "Two Prides in Family", the third copy of "Meteor Butterfly Sword" and the fourth copy of "heroes shed no tears" are all based on Gu Long’s works, which are slightly unfamiliar to ordinary readers, and may be a little fresh for book lovers who are used to seeing Jin Yong.

Generally speaking, this is a buried masterpiece, and some copies may be humbled, but the author will remind in advance that skipping a whole copy will not affect reading coherence.

Recommended index, three stars.

"I became a dragon mother" by hot sauce Regan Noodles.

The female sovereign travels with the same person to farm, and tends to be happy and funny.

The magical male author wrote the article about the heroine’s hegemony. The protagonist crossed into a pregnant dragon mother daenerys targaryen, and there was no love story. It is mainly about the protagonist riding a dragon, spraying fire on people, conquering the world, playing magic, playing different ghosts, and tossing Jon’s little demons. He will not make enemies without brains, but he will also fight decisively. Not the virgin, not killing people. The plot mainly follows fire and ice.

The author is familiar with the original work, the character analysis is in place, all kinds of plots are reasonable, and it is a set control, and the writing is thin and dense. Therefore, on the whole, the organization is clear, the writing is smooth, and it is quite fun. The farming is quite innovative, but it is slow at the beginning and needs some patience. It should be noted that the author’s consideration in the political field is not comprehensive enough, and the political system and legal construction seem to be taken for granted, especially the section of controlling Ma Wang’s men with the Manchu Eight Banners system. Although it is just a spoof, it has passed in a dozen chapters, but it has caused some controversy.

Recommended index, three to four stars, book lovers who like farming can try it boldly.

Flying over the bubble age by diagonal chord

Showa’s Japanese entertainment articles are full of amorous feelings.

The novel tells the story of China’s cross-dressers in the Japanese bubble era. The protagonist resigned as a waiter to become an underground artist’s agent from scratch, then started a band and later transformed into a film and television music company.

The story is a little mild and slow, but the content is good. It can be seen that the author has worked very hard on the information. Because of abundant information, the protagonist’s behavior style conforms to Japanese thinking, and there is no frivolous success, no enterprising and lonely courage, and no stinking rice circles and obsequiousness in Japanese entertainment novels. It well shows the situation of Japanese entertainment in the 1980 s. It is reasonable to read, and the novel is another impressive one.

It should be noted that the rhythm of the novel is slow, the sense of career promotion is weak, and the author is "keen" on stock trading. More than 400 chapters have not yet been determined, and the whole is too dull. Just like watching Japanese dramas and movies, there is no ups and downs, so it is easy to put it down and you can’t pick it up …

Recommended index, between three and four stars, book lovers who want to experience Showa style can give it to Xiancao.

"Ming Zun" by Chen Shiyi

Brain hole to Xianxia infinite flow, open lower and go higher.

The author’s new book "Fantasy World Crossing", the protagonist is Tai Shang’s personal treasure, who is born by weight, and is a master figure. He has his own understanding of repairing the truth and is decisive. He wears a seven-fold vest and pretends to be Meng Xin, and enters the space of the Lord God to compete with a group of Meng Xin. Congenital dramatists perform Tao and Gou Tao. As the saying goes: "Master Chen kills three thousand worlds, while Master Qian gives three thousand worlds".

It should be noted that the novel feels a little low and high. At the beginning, it was criticized (quite a few) that there were too many supporting roles, and a lot of space was spent on the introduction of world settings. By the time the reincarnation task began, it became more and more exciting, and it was full of Xianxia spirit. At present, it has a strong sense of paying tribute to "The Honor of I", and even the stalks of Mang King Kong began to play.

Generally speaking, it’s really a good book. It’s wonderful to stick to the copy of the team (The Hunger’s copy will be praised by five stars). I can feel that the author is deliberately adjusting the rhythm to face a wider reading group. In the past, it was a bit too heavy on the brain setting and despised the plot design. This is one reason why it was criticized at the beginning.

Recommended index, four stars.