月度归档： 2025 年 4 月

　　21st century business herald reporter Zheng Zhiwen Intern Wang Qingwei Shanghai Report

　　On November 25th, Chengdu Longquanyi Public Security Bureau reported a traffic accident on Chengluo Avenue in the district. When a small car was driving in the direction of Xihe River at the Shiling Interchange ramp of Chengluo Avenue, it collided with the vehicle in front at the intersection of Shiling subway station. Three people were slightly injured in the accident and all were treated in the hospital.

　　According to the video taken by the driving recorder of the rear vehicle, all the vehicles were waiting for the traffic lights at the intersection, and a white Tesla car suddenly rushed out and hit more than a dozen cars in a row. The scene of the accident was a mess, car parts were scattered all over the place, and many cars were seriously damaged.

　　On November 27th, Tesla responded to the cause of the accident. Tesla said that by checking the background data, it was found that when the collision occurred in the video, the accelerator pedal of the accident vehicle was depressed at a depth of 100%, and the vehicle speed increased from 54km/h to 132km/h at the time of collision. However, the brake light was not turned on because the driver stepped on the brake pedal, but because the collision in the video was not the first collision. After the first collision, the "multi-collision braking" function of the vehicle was triggered, so the brake light was turned on in the video. The background data also shows that the driver did not step on the brake pedal within 2 seconds after the collision in the video.

　　In view of the fact that the vehicle did not stop in time, Tesla said that by checking the background data, the driver stepped on the brake pedal 2 seconds after the collision in the video. However, combined with the background data and the damaged state of the vehicle, after the first collision, the front wheel of the vehicle has fallen off, the braking system pipeline has been damaged, and the vehicle has been unable to brake normally.

　　It is worth noting that this accident is not the first storm in Tesla’s braking, and related "brake failure" incidents have emerged in an endless stream in recent years.

　　The whole story of "Shanghai Auto Show Roof Rights Protection Event"

　　At the 2021 Shanghai Auto Show, two Tesla owners dressed in "brake failure" made a big fuss about Tesla booth demanding rights protection. Since then, Tesla has been shrouded in the suspicion of "brake failure".

　　On the afternoon of the auto show, Tao Lin, vice president of Tesla China, responded to this matter: Tesla had no way to compromise. The next morning, Weibo, the official of Qingpu Branch of Shanghai Public Security Bureau, issued a notice saying: Zhang, a woman involved in the "Tesla Auto Show Encountered Owners’ Rights Protection" incident, was sentenced to administrative detention for five days for disturbing public order, and Li was given an administrative warning for disturbing public order.

　　Since then, the two sides have opened the curtain of going to court, and whether Tesla has "brake failure" has also attracted much attention.

　　On May 6, 2021, Ms. Zhang formally sued Tesla (Shanghai) Co., Ltd., Tesla (Beijing) Co., Ltd. and Tao Lin, global vice president of Tesla. Ms. Zhang believes that after the rights protection incident at the Shanghai Auto Show, some remarks made by Tao Lin and Tesla officials were intended to create a negative image of the plaintiff’s unreasonable troubles and professional car troubles, which violated their reputation and caused troubles to their lives. These remarks include "all the recent negatives are her contribution", "only willing to pay high compensation" and the so-called "there is a team from Beijing". Ask the defendant to stop the infringement of the plaintiff’s reputation right, apologize to him and pay 50 thousand yuan for mental damage.

　　Two years later, Tesla issued a document in response to the failure of the female car owner of Tesla’s roof rights protection: the female car owner of Shanghai Auto Show advocated that the woman sued Tesla’s reputation right dispute case and personal information protection dispute case. After trial, the court of first instance decided to reject all the claims of Ms. Zhang in the two cases. On November 22, 2023, Tesla v. the case of infringement of the reputation right of female car owners in Xi ‘an "Shanghai Auto Show Incident", the court made a first-instance judgment, and found that Ms. Li in Xi ‘an was guilty of reputation infringement, and she had to publicly apologize to Tesla and compensate for the losses, and at the same time bear the vehicle appraisal fee.

　　Recently, according to Tesla’s news, the court made the latest judgment in the case of Tesla v. another female car owner in Xi ‘an, who was involved in the right to defend the roof of Shanghai Auto Show, and found that Ms. Li in Xi ‘an was guilty of reputation infringement, and she had to apologize to Tesla publicly and pay 2,000 yuan, and at the same time bear the vehicle appraisal fee of 20,000 yuan. After identification, there is no braking problem in the vehicle involved.

　　It is reported that before this, the judgment was made in December 2021, and the result was that Ms. Li won the case. Tesla then filed an appeal, and the Xi ‘an Intermediate People’s Court ruled that the case was sent back for retrial. On November 9, 2023, the weiyang district court made a new judgment, and the verdict was that Ms. Li lost the case. For the result of Tesla’s victory in the first instance, Ms. Li said that she respected the court’s decision, but she would appeal again.

　　It is worth noting that in March 2021, Weibo, the "Tesla Customer Support", said that the accident liability certificate issued by the traffic police showed that Mr. Zhang (the owner’s father) was found to have violated the relevant laws on safe driving and keeping a safe distance from the vehicle in front, and should bear full responsibility for the accident.

　　After the "Shanghai Auto Show Rights Protection" took place, Tesla provided the data one minute before Ms. Zhang’s vehicle accident, and made a written explanation, which stated that when the driver stepped on the brake pedal for the last time, the data showed that the vehicle speed was 118.5 kilometers per hour. Within 2.7 seconds after the driver stepped on the brake pedal, the maximum brake master cylinder pressure was only 45.9bar. After that, the driver stepped on the brake pedal more, and the brake master cylinder pressure reached 92.7bar. Then, the forward collision warning and automatic emergency braking function started (the maximum brake master cylinder pressure reached 140.7bar) and played a role, reducing the collision amplitude. 1.8 seconds after the ABS action, the system recorded the collision. After the driver stepped on the brake pedal, the vehicle speed continued to decrease, and before the collision, the vehicle speed decreased to 48.5 kilometers per hour. Through the inspection and analysis of vehicle data and on-site photos, it is found that ABS works normally during the braking period of the vehicle, and the functions of forward collision warning and automatic emergency braking are started and played a role, and no abnormality is found in the vehicle braking system.

　　At this point, the dispute over rights protection at the Shanghai Auto Show has also come to an end for the time being. Although Tesla won the rights protection, the price it paid was also heavy. In the face of rights-defending car owners, Tesla CEO Musk dissolved the public relations department and showed a tough attitude of refusing to apologize. Tao Lin, global vice president of Tesla, publicly told the media that Tesla had no way to compromise and asked consumers to strengthen education and study. This attitude caused dissatisfaction among many car owners in China, which made Tesla’s share price plummet at that time, and its market value evaporated by hundreds of billions of dollars overnight.

　　In the lawsuit with Ms. Li, Tesla asked Ms. Li to pay 5 million yuan in the first instance, but the amount of compensation awarded was only 2,000 yuan. On November 27th, Tesla said that it would continue to appeal. The incident caused huge losses to it, and the loss of Tesla’s orders and goodwill was as high as 100 million yuan as assessed by the judicial evaluation agency.

　　Give up the "single pedal" mode

　　In the storm of Tesla’s "brake failure", the "single pedal" mode seems to have become the target of public criticism.

　　This year, Tesla recalled 1.1 million Tesla cars around the world. The announcement on the website of the General Administration of Quality Supervision, Inspection and Quarantine once said that drivers were not allowed to choose the energy recovery braking strategy for vehicles within the scope of this recall; At the same time, it may not provide enough reminder for the driver to step on the accelerator pedal for a long time. The superposition of the above factors may increase the probability of mistakenly stepping on the accelerator pedal for a long time, which may increase the risk of collision and pose a safety hazard.

　　In the analysis of professionals, Tesla’s kinetic energy recovery technology is the strongest in the industry. Through kinetic energy recovery, it can save about 20% of energy and improve the endurance by about 15%-20%. Moreover, Tesla’s energy recovery mode is mandatory default mode, and the owner can’t set it by himself and can’t choose to turn it off. Most of the energy recovery modes of other electric vehicles on the market give the owners the freedom to choose.

　　Many users reported to 21st century business herald that the "single pedal" mode was not suitable for use at first, but it was really "fragrant" after being used to it, but some users still could not accept the "single pedal" mode.

　　Tesla said that the "single pedal" mode is more convenient and efficient. However, there are also risks. A survey report in 2021 showed that the National Highway Traffic Safety Administration (NHTSA) had investigated 246 cases of Tesla’s runaway acceleration, and all 246 cases were caused by stepping on the wrong pedal.

　　"There is no evidence that there is any fault in the accelerator pedal assembly, motor control system or braking system that leads to accidents, and there is no evidence that design factors will increase the possibility of pedal misuse." NHTSA said.

　　The so-called "single pedal" mode, in simple terms, can realize starting, accelerating, decelerating (braking) and other operations only by controlling the switch pedal. In this mode, kinetic energy recovery can not only save electricity, but also reduce the use of brakes, which can improve the cruising range of electric vehicles. Although the "single pedal" mode is not only equipped with one pedal, it is still equipped with a brake pedal. However, in this mode, users put their feet on the accelerator pedal instead of the brake pedal for a long time, which changes the way users are used to driving traditional fuel vehicles, but there may be potential safety hazards in an emergency.

　　Tesla has cancelled the "Kinetic Energy Recovery Adjustment Option" since the beginning of 2021, that is, on Tesla cars, this function is mandatory, not a switchable option. According to Tesla, after the OTA recall, car owners who like energy recovery braking can continue to choose the "standard" mode, and control the speed by "foot feeling", while improving the endurance of the vehicle by 10%-20% and reducing the wear of brake discs and pads. Car owners who are not used to this function can now choose the "low" mode to transition.

　　Although Tesla returned the option of kinetic energy recovery to the public, there are still other doubts that not recognizing the wrong operation of the owner can explain all the accidents of Tesla vehicles out of control and brake failure. Tesla’s roof rights car advocates that the top of Ms. Weibo is the video of Tesla Hainan accident released by another well-known Tesla rights car owner. The car owner can’t step on the brakes, but the staff will open the video that still can’t step on the brakes. In its latest Weibo, it forwarded a video recorded by another Tesla owner who obviously stepped on the brake system but mistook the owner for stepping on the accelerator.

　　There is also a question about whether Tesla’s data is reliable. "All data collection is based on Tesla’s unilateral provision, and Tesla only records the data collected by itself in the background. Is this data record objective? For example, if the owner steps on the brake, but can’t step on it, is it recorded in the background that he didn’t step on it? The owner did not step on the acceleration, and the vehicle automatically accelerated. Will the background also be recorded as acceleration, which means that the owner is stepping on the switch? "

　　Regarding the data problem, industry experts also said that there is no institution in China that has the professional ability to detect the data of smart electric vehicles. Zhang Xiang, a member of the automotive industry expert think tank of the Ministry of Industry and Information Technology, said in an interview with the media: "Now the institutions on the market basically only test mature and long-developed technologies, that is, mainly test traditional cars. As a smart car, Tesla can’t be tested according to the standards of traditional cars. Moreover, Tesla’s time to market is not long, and the technical iteration is changing with each passing day. Our regulations and industry standards have not kept up. "

　　There have been different opinions about the real cause of Tesla accident. Whether it is the owner’s "habitual thinking" or the quality of car design, the result of frequent vicious traffic accidents is unacceptable. At the moment of rapid development of new energy vehicles, car safety is the most important issue, and it needs the joint efforts of many parties to form effective supervision.

All relevant units:

　　The Measures for the Rapid Review and Approval of Medical Devices in Beijing have been deliberated and adopted at the 5th Director’s Office Meeting of Beijing Food and Drug Administration in 2018, and are hereby issued, please follow them.

Beijing Food and Drug Administration

February 9, 2018

Measures of Beijing Municipality for the Examination and Approval of Rapid Review of Medical Devices

　　the first　According to the requirements of the Notice of the General Office of the State Council City, the General Office of the Central Committee of the CPC on Printing and Distributing Opinions on Deepening the Reform of Review and Approval System and Encouraging the Innovation of Medicines and Medical Devices (Z.Z. [2017] No.42), according to the Regulations on the Supervision and Administration of Medical Devices, the Measures for the Administration of the Registration of Medical Devices, the Measures for the Administration of the Registration of In-vitro Diagnostic Reagents and the Policy Matters of the Food and Drug Administration on Supporting the Supervision and Industry Development of Zhongguancun, In order to encourage innovation, encourage the transformation of scientific and technological achievements, improve the efficiency of examination and approval of medical devices in Beijing, and promote the rapid development of medical device industry in Beijing, these measures are formulated.

　　the second　For Beijing medical device products that meet one of the following circumstances, the applicant may apply to Beijing Food and Drug Administration for approval of innovative medical devices:

　　(1) Having relevant national and Beijing scientific research projects, and the patents of core technology inventions involved have been made public or authorized.

　　(2) The invention patent of the core technology, which is the first in Beijing, has the leading product technology in China, has great clinical application value and is involved, has been made public or authorized.

　　(3) Patents for core technology inventions produced by key enterprises in Beijing, such as the 100-thousand-cultivation project and the Beijing Biomedical Industry Leap-forward Development Project (G20), have been made public or authorized.

　　(four) included in the national or Beijing major science and technology projects, key research and development plans;

　　Article　For the implementation of innovative medical devices in accordance with the provisions of Article 2 of these Measures, the person in charge shall be responsible, and early intervention, whole-process counseling, priority registration and testing, priority review and approval, priority registration quality system verification and priority production license matters shall be handled. See Annex 1 for the application requirements of innovative medical devices in Beijing.

　　Article 4　According to the application of the enterprise, Beijing Medical Device Technology Evaluation Center provides pre-consulting services for innovative clinical trial schemes of medical devices that meet the requirements of Article 2 of these Measures.

　　Article 5　For innovative medical devices that meet the requirements of Article 2 of these Measures, enterprises may entrust Beijing medical device manufacturing enterprises to produce products, and the medical device production license of the entrusted party shall obtain the corresponding production scope.

　　Article 6　For innovative medical devices, a cross-disciplinary joint evaluation method can be implemented.

　　Article 7　For innovative medical devices in Beijing that have been listed in the first registration cycle, all adverse medical device events of the product shall be reported and a summary report on monitoring, analysis and evaluation of adverse medical device events shall be submitted to the Beijing medical device adverse event monitoring technical institution and the food and drug administration department in the jurisdiction every year.

　　Article 8　For Beijing medical device products that meet one of the following circumstances, the applicant may apply to Beijing Food and Drug Administration for priority approval of medical devices:

　　(1) It is urgently needed in clinic, and there is no product of the same variety approved for registration in China;

　　(two) the varieties of medical devices belonging to the Beijing medical materials reserve unit and the unique and frequently-occurring diseases of children or disabled people;

　　(3) Diagnosing or treating rare diseases with obvious clinical advantages;

　　(four) for the treatment of serious life-threatening diseases and there is no effective treatment, as well as public health and other urgent needs;

　　(5) Intelligent rehabilitation apparatus;

　　(six) Beijing innovative medical device products to improve the production process.

　　Article 9　For medical device products that meet the requirements of Article 8 of these Measures, priority shall be given to registration and testing, priority shall be given to review and approval, priority shall be given to the verification of registration quality system, and priority shall be given to the handling of production licensing matters. Please refer to Annex 2 for the application requirements for priority approval of medical devices in Beijing.

　　Article 10　For the change of medical device registration license matters, the specification of product name, product technical requirements, scope of application, etc. does not involve substantial content changes, which can be combined with the renewal of registration.

　　Article 11　If the recommended standards, the guiding principles of registration technology review and the norms of registration technology review change in the renewal registration of medical devices, the enterprise may not change the licensing matters.

　　Article 12　If the specifications and models of medical devices are reduced, they can be handled in accordance with the registration procedures.

　　Article 13　For in vitro diagnostic reagent products, it is not necessary to submit analytical performance evaluation data, risk analysis data related to product changes, product technical requirements, product specifications and label samples by increasing the packaging specifications with different loading quantities (only the loading differences) and adding the changes of licensing items for applicable models with the same degree of automation. The time limit for registration review was shortened to 30 working days.

　　On the basis of strictly implementing the requirements of the quality system, the enterprise completes relevant risk analysis, performance evaluation, design changes, etc., and keeps records for future inspection.

　　Article 14　Those who fail to apply for registration renewal six months before the expiration of the validity period shall be registered for the first time. If the product has not changed, the latest registered clinical data, registration test report and system verification results may be submitted.

　　Article 15　Formulate the technical guidelines for clinical evaluation of medical devices in Beijing, study the comparison methods of similar medical devices, and simplify the clinical evaluation data of the same variety of medical devices.

　　Article 16　Beijing Medical Device Technology Evaluation Center has established a communication mechanism for enterprises to solve the difficult problems encountered by enterprises in the registration and evaluation stage of medical devices.

　　Article 17　Integrate the on-site inspection of the registered quality system verification and the on-site inspection of the production license. In principle, after the on-site inspection of the new product registration quality system verification has passed and the medical device registration certificate has been obtained, the products added to the Medical Device Production License can be exempted from the on-site inspection.

　　Article 18　For enterprises that have obtained production licenses, applying for the registration of Class II medical devices that do not involve new methodology or new technology may be exempted from on-site inspection or optimization of on-site inspection items and processes in the process of registration quality system verification.

　　Article 19　If the contents of the change of medical device registration license items do not involve the change of production process, the on-site inspection may be exempted or the on-site inspection items and processes may be optimized in the process of registration quality system verification.

　　Article 20　For those who have passed the on-site inspection of registered quality system verification at least once in two years, and the products applied for inspection this time have the same or similar working principles and expected uses compared with those that have passed the inspection, and have basically the same structural composition, production conditions and production processes, they are exempted from on-site inspection or optimized on-site inspection items and processes in the process of registered quality system verification.

　　Article 21　If the production address is reduced and the production process changes are not involved, the on-site inspection can be exempted or the on-site inspection items and processes can be optimized during the approval of the production license.

　　Article 22　In principle, on-site re-inspection is not required if no key project defects are found in the on-site inspection of the registered quality system, and the number of general project defects accounts for less than 10% of the total number of general projects that should be inspected.

　　Article 23　If the on-site inspection of the production license requires the enterprise to carry out rectification, the enterprise may be required to submit rectification report and rectification data according to the situation of the on-site inspection and the rectification items, and the on-site re-inspection is not required if it can be verified through the data.

　　Article 24　Optimize the registration examination and approval procedures, and cancel the following examination and review links in the administrative examination and approval of medical device registration:

　　(1) First registration of Class II medical device products (including in-vitro diagnostic reagents) that fully implement the guiding principles of product registration technology review issued by china food and drug administration or the product registration technology review norms issued by Beijing Food and Drug Administration;

　　(two) the second class of medical devices (including in vitro diagnostic reagents) continued registration;

　　(three) the second kind of medical devices (excluding in vitro diagnostic reagents) product description changes;

　　(four) the second kind of medical devices (including in vitro diagnostic reagents) product registration certificate error correction.

　　Article 25　These Measures shall not apply to domestic applicants who apply for approval of innovative medical devices to Beijing Food and Drug Administration according to the Notice of the General Administration of Food and Drug Administration on Printing and Distributing Special Approval Procedures for Innovative Medical Devices (Trial) (No.13 [2014] of the Food and Drug Administration).

　　Article 26　These Measures shall be interpreted by the Beijing Food and Drug Administration.

　　Article 27　These Measures shall come into force as of the date of promulgation. The Measures for the Examination and Approval of Medical Devices in Beijing (Trial) issued on August 11, 2016 (Beijing Food and Drug Administration [2016] No.36) was abolished at the same time.

　　Attachment: 1. Requirements for reporting innovative medical devices in Beijing.

　　 　 　 　2. Requirements for priority examination and approval of medical devices in Beijing

Annex 1

Requirements for reporting innovative medical devices in Beijing

　　In order to standardize the application for innovative medical devices in Beijing and improve the quality of application materials, this application requirement is formulated in accordance with the Measures for the Examination and Approval of Rapid Medical Devices in Beijing.

　　I. Application materials for innovative medical devices in Beijing

　　(a) Beijing innovative medical device review application form (Annex 1)

　　The applicant shall truthfully fill in all the contents.

　　The contents filled in the product performance structure and composition, main working principle/action mechanism and expected use should reflect all the important information of product characteristics, be concise and to the point, use standardized and professional terms, and avoid ambiguity.

　　(2) Relevant information of previous applications for innovative medical device approval (approval) (if applicable)

　　If the product has applied for innovative medical device products from china food and drug administration or Beijing Food and Drug Administration, for the innovative medical devices that have been applied for again, copies of previous notices shall be provided, and explanations on product changes and improvement of application materials shall be submitted.

　　(3) A photocopy of the business license of the enterprise to which it applies.

　　(four) the intellectual property rights of the products and the supporting documents.

　　1. Provide a description of the intellectual property rights of the core technology of the innovative medical device applied for. If there are many invention patents, it is suggested to display the information such as the name of the invention patent, the patentee and the patent status in a list.

　　2. Provide relevant intellectual property documents.

　　(1) If the applicant has obtained the patent right for invention, it is required to provide the original copy of the patent power of attorney, the patent claim, the specification and the copy of the patent register signed by the applicant.

　　(2) If the applicant has obtained the right to use the invention patent in China through the transferee according to law, in addition to submitting the copy of the patent authorization, patent claim, specification and patent register held by the patentee, it is also necessary to provide the original Certificate of Filing the Patent License Contract issued by the patent administrative department.

　　(3) If the application for a patent for invention has been made public by the patent administration department of the State Council and is not authorized, it is necessary to provide a copy of the proof document of the publication of the invention patent signed by the applicant (such as the notice of publication of the application for a patent for invention, the notice of publication of the application for a patent for invention and the notice of entry into the substantive examination stage, etc.) and a copy of the published version of the claim and specification. In the process of examining an application for a patent for invention, if the patent claim and specification are modified at the request of the patent examination department, the modified text shall be submitted; Where the patentee changes, the certifying documents issued by the competent patent department, such as a copy of the notice of conformity, shall be submitted.

　　(V) Summary of product development process and results

　　Summarize the original intention of product research and development, laboratory research, animal experimental research, clinical research and results, and submit a comprehensive report on product research and development including design input, design verification and design output. Information on patient selection criteria, as well as parameters to be monitored and factors to be considered during use.

　　(6) Product technical documents, which shall at least include:

　　1. The intended use of the product;

　　(1) It should be made clear that the treatment and diagnosis expected to be provided by the product conform to the purpose defined in Article 76 of the Regulations on the Supervision and Administration of Medical Devices, and the applicable medical stage (such as monitoring and rehabilitation after treatment) can be described;

　　(2) explain whether the product is used once or repeatedly;

　　(3) A description of the equipment expected to be used in combination with it;

　　(4) Information of the target patient population (such as adults, children or newborns).

　　2. Working principle/action mechanism of the product;

　　Elaborate the working principle/mechanism of the product to achieve its expected use, and provide relevant basic research data.

　　3. Make clear the main technical indexes of products and the basis for determination, the index requirements of main raw materials and key components, the main production process and flow chart, and the inspection methods of main technical indexes.

　　(seven) certification documents of product innovation, which shall at least include:

　　1. Novelty retrieval report issued by information or patent retrieval institutions.

　　It should be a sci-tech novelty report issued by information retrieval institutions in China or a novelty report issued by patent retrieval institutions. The contents of the report should be able to prove the innovation point, innovation level and reasons of the product. The novelty retrieval report is valid for one year.

　　2. Summary of academic papers, monographs and documents published in core journals that can fully explain the clinical application value of products (if any)

　　Can provide product literature, but also provide overseas literature of similar products.

　　3. Analysis and comparison of the application of similar products listed at home and abroad.

　　(1) Provide a description of the retrieval of similar products that have been listed in China. Generally, it should include the retrieval database, retrieval date, retrieval keywords and the results retrieved by each keyword, and analyze the differences between the applied innovative medical devices and similar products on the market in terms of working principle/mechanism.

　　(2) Provide an explanation of the application of similar products listed overseas, compare and analyze the similarities and differences with this product, and provide comparative analysis data to support this product to be at the international leading level in technology.

　　4. The innovative content of the product and its remarkable value in clinical application.

　　(1) Overview of innovative medical devices applied for.

　　This paper expounds the innovative contents of the applied medical device, and discusses that the device has been significantly improved in terms of safety, effectiveness and economy compared with the existing products or treatment methods through innovation, and has significant clinical application value.

　　(2) Provide relevant supporting materials.

　　(eight) product safety risk management report.

　　1. Based on the research results of the risk management process carried out by the product.

　　2. Prepared according to YY/T 0316 "Application of Medical Device Risk Management to Medical Devices".

　　(9) Product description (sample draft).

　　It shall comply with the relevant requirements in the Regulations on the Administration of Instructions and Labels of Medical Devices (Order No.6 of the General Administration).

　　(ten) other documents that prove that the product conforms to Article 2 of the Measures for the Examination and Approval of Medical Devices in Beijing.

　　1. If the product or its core technology has won national and Beijing municipal science and technology awards, please explain and submit copies of relevant supporting documents;

　　2. The approval certificate of key supporting enterprises in Beijing, such as the 100 thousand cultivation project and the Beijing biomedical industry leap-forward development project (G20).

　　3 included in the national or Beijing major science and technology projects, key research and development plan documents.

　　(eleven) the self-assurance statement of the authenticity of the submitted materials.

　　Second, the format requirements

　　(a) the application materials shall be compiled by the applicant, and the documents shall be printed on A4 paper, arranged in the order specified in this acceptance requirement and bound into a book.

　　(two) there should be a list of submitted materials, including the first and second titles of the application materials. The data corresponding to each secondary heading shall be separately numbered.

　　(3) Unless otherwise specified, the application materials for the review of innovative medical devices in Beijing shall be original and signed by the applicant. "Signature" refers to the seal of the enterprise, or the signature of its legal representative and responsible person plus the seal of the enterprise.

　　(four) if the application materials are in photocopy, the photocopy shall be clear and consistent with the original. Color pictures and charts shall be provided with color copies. If the original application materials have been submitted in the previous application for examination of innovative medical devices, a copy signed by the applicant can be provided, and the applicant will issue a document stating the acceptance number of the application materials where the original application materials are located.

　　(5) The application materials shall be in Chinese. If the original text is in a foreign language, there should be a Chinese translation.

　　Third, the review process

　　To apply for innovative medical device products in our city, after the above materials are prepared, they shall be reported to the Medical Device Registration and Supervision Department of the Municipal Bureau (hereinafter referred to as the "Device Department"), and the Device Department shall formally review the application materials, and issue a receipt document (Annex 2) within 5 working days; The device will be reviewed by relevant experts within 40 working days, and the applicant and product name will be publicized on the website of Beijing Food and Drug Administration for 10 working days for the varieties to be included in Beijing’s innovative medical devices. If there is no objection after the publicity period, a final review opinion will be issued, and a notice of review of innovative medical devices in Beijing (Annex 3) will be made to inform the applicant in writing.

　　Attachment: 1. Application Form for Review of Innovative Medical Devices in Beijing

　 　 　 　　2. Beijing Innovative Medical Devices Review Receipt Certificate

　 　 　 　　3. Notice of Review Opinions on Innovative Medical Devices in Beijing

Annex 1 of Beijing Municipality’s Declaration Requirements for Innovative Medical Devices

Annex 2 of Beijing Municipality’s Declaration Requirements for Innovative Medical Devices

Beijing Innovative Medical Device Review Receiving Material Voucher

(first copy)

　　(Receiving material number: _ _ _ _ _)

　　：

　　Your company applied for the examination of innovative medical devices in Beijing. After formal examination, the application materials are complete and it is decided to accept it. A total of _ _ pieces of materials were received.

　　Tel: 010-83979525

　　Receiver’s signature: year month day

Beijing Innovative Medical Device Review Receiving Material Voucher

(second copy)

　　(Receiving material number: _ _ _ _ _)

　　：

　　Your company applied for the examination of innovative medical devices in Beijing. After formal examination, the application materials are complete and it is decided to accept it. A total of _ _ pieces of materials were received.

　　Tel: 010-83979525

　　Signature of the applicant: year month day

Annex 3 of Beijing Municipality’s Declaration Requirements for Innovative Medical Devices

Notice of Beijing Municipality on Review Opinions of Innovative Medical Devices

　　(No.:_ _ _ _ _)

　　The application for examination of innovative medical devices in Beijing submitted by your company (receiving material number:)

　　Performance structure and composition:

　　Main working principle/mechanism:

　　The conclusion of the review is:

.

　　I hereby inform you.

(Seal)

Date:

Annex 2

Requirements for Priority Approval and Declaration of Medical Devices in Beijing

　　In order to standardize the application for priority approval of medical devices and improve the quality of application materials, this application requirement is formulated in accordance with the Measures of Beijing Municipality for Rapid Review and Approval of Medical Devices (Revised).

　　First, Beijing gives priority to the examination and approval of medical device application materials.

　　(1) Application Form for Priority Approval of Medical Devices (Annex 1)

　　Clearly explain the circumstances specified in Article 14 of the Measures for the Rapid Review and Approval of Medical Devices in Beijing (Revised), and briefly describe the reasons for priority approval.

　　(two) a copy of the application form for registration of medical devices.

　　(three) in accordance with the "Beijing medical device rapid review and approval measures" eighth cases of medical device priority approval application, should provide information according to the following requirements:

　　1 clinical needs, and there is no product of the same variety approved for registration in China.

　　(1) Summary of the clinical treatment status of the indications of this product, explaining the reasons for urgent clinical need;

　　(2) The overseas approval and clinical use of this product and similar products;

　　(3) Provide a description of the search, which proves that there are no related products of the same variety approved for registration in China at present, and there is no equivalent alternative diagnosis or treatment method at present.

　　2. The medical device reserve varieties belonging to the Beijing medical material reserve unit and the medical device varieties used by children or disabled people with unique and multiple diseases.

　　(1) the certificate of entering the catalogue of medical material reserve units in Beijing;

　　(2) The indication of this product belongs to the supporting data of unique and frequently-occurring diseases of children or disabled people;

　　(3) Summary of the clinical treatment status of this indication;

　　(4) Description and relevant supporting materials proving that the product is specially used for diagnosing or treating unique and frequently-occurring diseases of children or disabled people, and has obvious clinical advantages compared with existing products or treatment methods.

　　3 diagnosis or treatment of rare diseases, and has obvious clinical advantages.

　　(1) Incidence data of the indications of this product and relevant supporting data;

　　(2) Supporting data to prove that the indication is a rare disease;

　　(3) Summary of the clinical treatment status of this indication;

　　(4) Description of the obvious clinical advantages of this product compared with the existing products or treatment methods and relevant supporting materials.

　　4 for the treatment of serious life-threatening diseases and there is no effective treatment, as well as public health and other urgent needs.

　　(1) To prove that the indication belongs to the urgently needed supporting information for treating diseases that are seriously life-threatening and have no effective treatment methods, and public health;

　　(2) Summary of the clinical treatment status of this indication;

　　(3) the product has obvious clinical advantages over the existing products or treatment methods, and relevant supporting materials.

　　5. Intelligent rehabilitation apparatus

　　(1) Medical devices that meet the definition of intelligent rehabilitation devices in the "Thirteenth Five-Year Plan for Scientific and Technological Innovation of Health Industry" (No.149 [2017] of National Science and Technology Development Agency);

　　(2) Summary of the clinical treatment status of this indication;

　　(3) the product has obvious clinical advantages over the existing products or treatment methods, and relevant supporting materials.

　　6. Improve the production process of innovative medical device products in Beijing.

　　(1) Notice of Review Opinions on Innovative Medical Devices in Beijing;

　　(2) Description of production process changes of new and old products.

　　(4) A self-assurance statement on the authenticity of the submitted materials.

　　Second, the format requirements

　　(a) the application materials shall be compiled by the applicant, and the documents shall be printed on A4 paper, arranged in the order specified in this acceptance requirement and bound into a book.

　　(two) there should be a list of submitted materials, including the first and second titles of the application materials. The data corresponding to each secondary heading shall be separately numbered.

　　(3) Unless otherwise specified, the application materials for the examination and approval of priority medical devices in Beijing shall be original and signed by the applicant. "Signature" refers to the seal of the enterprise, or the signature of its legal representative and responsible person plus the seal of the enterprise.

　　(four) if the application materials are in photocopy, the photocopy shall be clear and consistent with the original. Color pictures and charts shall be provided with color copies. If the original application materials have been submitted in the previous priority examination and approval of the medical device application, a copy signed by the applicant can be provided, and the applicant will issue a document stating the acceptance number of the application materials where the original application materials are located.

　　(5) The application materials shall be in Chinese. If the original text is in a foreign language, there should be a Chinese translation.

　　Third, the review process

　　To apply for the priority approval of medical device products in our city, after the above materials are prepared, they shall be reported to the Medical Device Registration and Supervision Department of the Municipal Bureau (hereinafter referred to as the "Device Department"), and the Device Department shall conduct a formal review of the application materials, and issue a receipt document (Annex 2) within 5 working days; The device shall be reviewed by relevant experts within 40 working days, and the applicant and product name shall be publicized on the website of Beijing Food and Drug Administration for 10 working days for the varieties of medical devices to be approved in Beijing. If there is no objection after the publicity period, a final review opinion will be issued, and a notice (Annex 3) for the review of medical devices with priority approval in Beijing will be made, and the applicant will be informed in writing.

　　Attachment: 1. Application Form for Priority Approval of Medical Devices in Beijing

　 　 　 　　2. Beijing Municipality gives priority to the examination and approval of medical devices, and receives the certificate of materials.

　　 　 　 　3. Notice of Beijing Municipality on Priority Examination and Approval of Medical Devices

Annex 1 of the Declaration Requirements for Priority Approval of Medical Devices in Beijing

Annex 2 of the Declaration Requirements for Priority Approval of Medical Devices in Beijing

Beijing Municipality gives priority to the examination and approval of medical devices.

(first copy)

　　(Receiving material number: _ _ _ _ _)

　　：

　　Your company applied for the examination of medical devices with priority approval in Beijing. After formal examination, the application materials are complete and it is decided to accept it. Total materials received　Pieces.

　　Tel: 010-83979525

　　Receiver’s signature: year month day

Beijing Municipality gives priority to the examination and approval of medical devices.

(second copy)

　　(Receiving material number: _ _ _ _ _)

　　：

　　Your company applied for the examination of medical devices with priority approval in Beijing. After formal examination, the application materials are complete and it is decided to accept it. Total materials received　Pieces.

　　Tel: 010-83979525

　　Signature of the applicant: year month day

Annex 3 of the Declaration Requirements for Priority Approval of Medical Devices in Beijing

Notice of Beijing Municipality on Priority Examination and Approval of Medical Devices

　　(No.:_ _ _ _ _)

　　Your application for the examination of medical devices in Beijing with priority approval (receiving material number:)

　　Performance structure and composition:

　　Main working principle/mechanism:

　　The conclusion of the review is:

.

　　I hereby inform you.

(Seal)

Date:

　　People’s Daily Online, Beijing, January 4 (Zhu Jiang) "China is one of the countries most seriously affected by marine disasters in the world." The reporter learned from the Ministry of Natural Resources that according to the statistics of the Marine Early Warning and Monitoring Department, in the past 10 years, the average annual direct economic loss of marine disasters was 11.7 billion yuan, with an average annual death (including missing) of 93 people. In recent 30 years, the average sea level rise rate in China is 3.3 mm/year, which is higher than the global average. Under the background of global climate change, the risk of major marine disasters along the coast is becoming increasingly prominent. With the rapid increase of marine economic activities, the offshore waters are seriously polluted and the marine ecological environment is destroyed.

　　During the institutional reform of the central and state organs, the Ministry of Natural Resources set up a marine early warning and monitoring department to fulfill the responsibilities of marine disaster prevention and mitigation, whose main responsibilities include "formulating policies and systems for marine observation and forecast and marine scientific investigation and supervising their implementation. To carry out marine ecological early warning and monitoring, disaster prevention, risk assessment and hidden danger investigation and management, and issue warnings and bulletins. Construction and management of the national global ocean stereoscopic observation network, and organization of marine scientific investigation and survey. Participate in emergency response to major marine disasters. "

　　Wang Hua, deputy director of the Marine Early Warning and Monitoring Department, made it clear that it provided an important organizational guarantee for the effective implementation of the principles, policies and decision-making arrangements of the CPC Central Committee and the State Council on the prevention and control of natural disasters. The first task of the Marine Early Warning and Monitoring Department is to do a good job in the top-level design of marine observation and forecast and marine scientific investigation, and the second is to continuously improve the basic capabilities of marine observation, monitoring and investigation, and further improve the marine early warning and monitoring business system. At the same time, it is necessary to make overall plans for the connection between marine disaster prevention and mitigation, land space planning and ecological protection and restoration.

　　At present, marine early warning and monitoring work faces five problems.

　　"What we are facing is a situation where challenges and opportunities coexist." On November 7, 2018, in a series of interview programs with the Director of the Department of Natural Resources, Wang Hua said that after years of development, marine observation, early warning and disaster reduction have formed a good working foundation. In 2012, the State Council promulgated the Regulations on the Administration of Marine observation and forecast, which filled the legal gap in the work of marine observation and forecast in China. After decades of development, the ocean observation business system has gradually formed, which consists of ocean station network, buoy network, radar network, volunteer ship, satellite remote sensing and so on, basically covering China’s inshore, offshore and some key sea areas. Established a marine forecasting system from national to local. The focus of disaster prevention and mitigation has been constantly moving forward, and the business system of marine disaster risk prevention has basically taken shape.

　　Wang Hua believes that the current marine early warning and monitoring work faces five problems. First, the laws, regulations and institutional standards of marine observation and forecast and related fields of disaster prevention and mitigation are not yet complete. Second, the basic ability still needs to be strengthened. The ocean view monitoring system needs to be further optimized, the ability of deep-sea observation is insufficient, the independent research and development of ocean forecasting and the application level of key technologies need to be improved, and the work of marine disaster risk assessment and hidden danger investigation has not been fully carried out. Third, the information resource sharing mechanism needs to be established. The sharing of information resources in disaster-related fields and the management and coordination of ocean observation activities still need to be strengthened. Fourth, the level of science and technology and the ability of global governance need to be improved, and the participation and voice of international ocean affairs governance are not enough. Fifth, it is necessary to further stimulate the vitality of the market and give full play to the role of market mechanisms and social forces in marine disaster prevention and mitigation.

　　The marine early warning and monitoring department should perform three responsibilities.

　　According to the data of China Organization Network, the main responsibilities of the Marine Early Warning and Monitoring Department are: to formulate policies and systems for marine observation and forecast and marine scientific investigation and supervise their implementation. To carry out marine ecological early warning and monitoring, disaster prevention, risk assessment and hidden danger investigation and management, and issue warnings and bulletins. Construction and management of the national global ocean stereoscopic observation network, and organization of marine scientific investigation and survey. Participate in emergency response to major marine disasters.

　　Wang Hua mentioned that the Marine Early Warning and Monitoring Department should perform three responsibilities: First, implement the important arrangements of the CPC Central Committee and the State Council for the prevention and control of natural disasters, and do a good job in the top-level design of marine observation and forecast and marine scientific investigation; The second is to continuously improve the basic capabilities of marine observation, monitoring and investigation, and strengthen the construction of marine ecological early warning and monitoring system; The third is to fully connect with relevant departments and make overall plans for marine disaster prevention and mitigation, land and space planning, ecological protection and restoration.

　　Wang Hua pointed out that in the past, China’s marine observation, forecasting and early warning, disaster reduction and other work were mainly aimed at the physical environment of the ocean and the process of natural disasters. In the future, we should focus more on the principle of realizing "two unifications" (that is, "the Ministry of Natural Resources uniformly exercises the duties of the owner of all natural resources assets of the whole people, and uniformly exercises the duties of controlling all land use and ecological protection and restoration"). For example, accelerate the construction of marine ecological early warning system to provide support for the effective protection of important, sensitive and fragile marine ecosystems; Efforts will be made to strengthen the connection between marine early warning and monitoring, national spatial planning and ecological protection and restoration.

　　The marine early warning and monitoring department will focus on three aspects.

　　Wang Hua said that in the field of marine early warning and monitoring, it is the basic work to dynamically monitor the state of marine resources and environment and grasp the basic situation. It is necessary to find problems through long-term series monitoring, and judge whether the carrying capacity of resources and environment is in a normal state through statistical analysis and evaluation of data, and issue early warning in time. At the same time, put forward some suggestions for specific problems.

　　In this regard, Wang Hua demanded that the next step should focus on three aspects: First, further rationalize the business system, make a good connection with other disaster-related ministries at the national level, and give full play to the supporting role of marine early warning and forecasting under the new emergency management framework to promote comprehensive disaster reduction; At the local level, strengthen guidance, coordination and supervision, and actively play the role of local authorities. At the same time, further clarify the responsibilities of the agencies in the sea area, and form a unified and orderly, reasonable division of labor, coordinated and efficient institutional mechanism.

　　Second, actively implement the requirements of the third meeting of the Central Financial and Economic Committee on the prevention and control of marine disasters, implement coastal zone restoration projects, build ecological seawalls, and improve the ability of ecosystems to defend against marine disasters.

　　The third is to implement the main responsibility and continuously improve business capabilities. In the "Sanding" plan issued by the Ministry, for the first time, the task of building and operating the national global marine stereoscopic observation network and carrying out marine ecological early warning and monitoring was clearly defined. As the competent department of business, the marine early warning and monitoring department should adhere to the scientific development concept and implement every link of the business chain in a down-to-earth manner.

　　To this end, the Marine Early Warning and Monitoring Division will focus on the following four aspects in the near future:

　　— In the observation business, do a good job in top-level design and accelerate the construction of the global marine stereoscopic observation network. Optimize the observation layout. In 2019, we will start to compile a new national ocean observation network plan, fully integrate the observation, monitoring and investigation services, and form a trinity business layout. From the aspects of observation means, observation elements and quality control, we will further strengthen the operational management of marine observation. Promote the sharing of marine observation data, improve the level of data services, strengthen the management of relevant industries of local and departmental departments, and carry out a general survey of marine observation capabilities and resources to achieve full integration.

　　Second, in the forecasting business, we should speed up the revision of emergency plans, and consider the respective characteristics of marine natural disasters and ecological disasters to study how to form a plan system. Reorganize the forecasting organization and business system, comprehensively consider the characteristics of administrative area management, and build a forecasting business system with up-and-down linkage and clear division of labor. Make full use of numerical forecasting, cloud platform, artificial intelligence and other information technologies, carry out the construction of marine intelligent grid forecasting business system and the "Maritime Silk Road" marine environmental protection system, explore the development of marine ecological early warning services, and improve the efficiency of early warning services.

　　Third, in disaster reduction, we will continue to do a good job in preventing and controlling natural disasters such as storm surges, tsunamis and sea ice. At the same time, we will promote ecological disaster reduction, select red tide and green tide-prone areas for pilot prevention and control, and give full play to the ability of mangroves, tamarisk, reeds, seagrass beds and other ecosystems to resist moisture and waves and consolidate dikes and revetments. Guide coastal areas to continue to carry out marine disaster risk assessment and delineation of key defense areas, and promote the investigation and management of potential risks. Strengthen the information application of disaster prevention and mitigation achievements, and integrate background information, observation data, early warning and pre-judgment information in coastal high-risk areas into one system in real time. Intensify publicity and education, popularize knowledge of disaster prevention and mitigation, and actively participate in international governance.

　　Fourth, in terms of ecological monitoring and scientific investigation, optimize the top-level design and system layout of marine ecological monitoring and early warning, establish a technical standard system, and start special research on typical ecosystems. Establish management norms, and institutions and ships engaged in marine survey and monitoring should have unified management requirements. Strengthen the use of volunteer ships, remote sensing and other equipment and means, and integrate development in monitoring, observation and investigation.

On Monday, April 16, 2018, the State Council Press Office held a regular briefing on the State Council policy, and invited Ceng Yixin, deputy director of the National Health and Wellness Committee, to introduce the relevant information on the Opinions on Promoting the Development of "Internet+Medical Health" and answer questions from reporters.

Jiao Yahui, Deputy Director of Medical Administration and Hospital Authority:

There are two modes in the document of Internet hospital: one mode is that medical institutions are the main providers, and medical institutions use Internet information technology to expand service time and space, and take Internet hospital as the second name of medical institutions. There is a very important principle that the services to be provided by Internet hospitals should be consistent with the relevant diagnosis and treatment subjects of entity medical institutions approved by us, that is to say, our hospital is a three-level general hospital, which subject is approved, and what content can Internet hospitals provide accordingly. The second is that some Internet companies and enterprises have applied for Internet hospitals. They have the resources of some high-quality experts, such as doctors in the north and the south of China, who use the platform provided by this Internet company to provide some services for patients. In this document, we require that Internet hospitals must be located in physical medical institutions, with consistent supervision online and offline, and must rely on physical medical institutions to provide patients with telemedicine services such as remote clinics through the Internet platform. Generally speaking, it is such a form.

The Internet hospital you mentioned just now, we are talking about not only Internet hospitals, but also Internet medical services are divided into two categories:

First, around our core business, that is, treating patients, it is generally said that whether the disease needs the next diagnosis, whether to propose a treatment plan and prescribe some prescriptions, this is called Internet diagnosis and treatment service, which is a kind of content of Internet service. We say it is the core business of medical care, and this Internet diagnosis and treatment service, as mentioned by Director Zeng and Director Yu just now, we are drafting and formulating management measures for Internet diagnosis and treatment. This is also a very important supporting document authorized by the National Health and Wellness Committee in the the State Council document. In this document, we will define the bottom line and boundary of Internet diagnosis and treatment, and within this boundary, we can provide some services. For example, as proved by practice now, it also includes internationally mature and recognized telemedicine services. In addition, there are family doctors who provide some health management and online consultation services for the patients he signed. It is stipulated in the document that some common diseases and chronic diseases can be followed up online, and the online follow-up service can also be provided through the Internet, and doctors can prescribe prescriptions for these patients online when they have mastered some basic case data of these patients, which is part of the Internet diagnosis and treatment service.

Second, non-core business, that is, we should provide some auxiliary services to take advantage of the convenience and convenience of the Internet. In this field, Internet technology has great room and great potential. Moreover, in practical application, it has been applied in many practices now, and patients in many places have enjoyed the convenience and bonus in this respect. For example, for example, many patients go to the hospital to see a doctor now, and they can register online and make appointments with a mobile phone, and when they come to the hospital, they can provide some reminders through the mobile phone when they arrive, and they can also pay by mobile phone without queuing up at the window. In addition, some inspection and inspection results can be queried online. This is a great bonus that patients can enjoy in the hospital, and everyone has personal experience. At the same time, we use the internet to sink the good resources of high-quality medical care. For example, the economy and medical care in remote and poverty-stricken areas are not very developed. Through telemedicine or remote outpatient service, some patients in some counties and some patients in remote and poverty-stricken areas can also see experts from these big hospitals in Beishangguang without leaving their place of residence, and they can enjoy this convenient service. We also have some decision-making assistance activities supported by artificial intelligence, including some grassroots doctors and doctors in county and city hospitals, which can greatly improve their medical service level and efficiency, and indirectly serve more patients.

We are now using it in family doctor contract service. For example, we have some rural patients, community patients, elderly people in the community and village clinics at home or at home, and contracted doctors can consult some questions online or at his place. For some problems, village doctors or contracted family doctors can’t solve them, and they can also seek help from the doctors in the superior hospital of this team through the Internet, so that patients can enjoy more convenient, daily health management and safe and appropriate diagnosis and treatment services at home, so I think these are what we say Internet hospitals or Internet diagnosis and treatment can provide.

As for the application procedure of Internet hospitals, because it is a new format, we will seriously solve the problems about the conditions that this kind of medical institutions should have, how to apply, and at which level for examination and approval, in line with the principles and requirements of "streamline administration, delegate power, strengthen regulation and improve services", and will make clear provisions in our management measures for Internet diagnosis and treatment. Thank you.

　　Is aspirin taken on an empty stomach or after meals??

　　Some patients taking aspirin for a long time may cause digestive tract damage. Aspirin-induced digestive tract injury is the result of local and systemic effects. The local effect is that aspirin directly stimulates the digestive tract mucosa, directly damages the gastric mucosa, and also damages the intestinal mucosal barrier. The systemic effect is that it reduces prostaglandin synthesis, and prostaglandin is a substance that can regulate gastrointestinal blood flow, stimulate the synthesis and secretion of mucus and bicarbonate, and protect gastric mucosa.

　　If you take aspirin enteric-coated tablets, there is an acid-resistant coating outside it, and the environment in the stomach is acidic. The acid-resistant coating can protect the acidic environment in the stomach from being dissolved and released, and then it can be slowly released and absorbed in the alkaline environment of the small intestine, thus reducing the direct stimulation to the gastric mucosa and the adverse reactions of the gastrointestinal tract. Therefore, aspirin enteric-coated tablets are recommended to be taken on an empty stomach. Furthermore, taking it on an empty stomach can shorten the retention time in the stomach, and then reach the absorption site of the small intestine smoothly, thus avoiding the gastrointestinal adverse reactions caused by the prolonged retention time in the stomach. However, if you use ordinary aspirin tablets instead of enteric-coated aspirin tablets, there is no such protective mechanism, and such aspirin should be taken after meals.

　　What time do you mean by fasting and after meals??

　　Taking medicine on an empty stomach actually means 1 hour before eating or 2 hours after eating. Taking medicine after meals does not mean taking medicine immediately after meals, but taking it 15-30 minutes after eating.

　　Should aspirin be taken in the morning or at night??

　　This issue is still inconclusive. Some experts believe that the viscosity of platelets at night is higher and the risk of thrombosis is higher, so aspirin should be taken at night to play its antiplatelet role; Some experts also believe that the risk of cardiovascular risk events in the morning is high, so it should be taken in the morning to prevent cardiovascular risk events.

　　Aspirin exerts its antiplatelet effect by irreversibly inhibiting cyclooxygenase, which can exist in the whole life cycle of platelets (about 10 days). Once it takes effect, its antiplatelet effect is persistent. Therefore, aspirin can be taken at any time of the day (morning, noon or evening), and it is important to take it regularly at the same time every day.

　　Can aspirin be taken apart??

　　In most cases, aspirin enteric-coated tablets can’t be opened for use, because the outer coating plays a protective role in gastric mucosa. If you take it open, it will destroy the surface coating and lose the protective effect of enteric-coated tablets. If the dosage is relatively large, aspirin enteric-coated tablets with smaller specifications can be replaced.

　　When can I chew it??

　　You need to chew it when you save yourself from myocardial infarction. Correct pre-hospital first aid is one of the key factors to reduce the mortality rate of myocardial infarction. If there are elderly people over 50 years old or patients with coronary heart disease at home, you should always keep aspirin and take it with you when you go out.

　　The typical symptoms of myocardial infarction are pain in the middle or left part of the sternum, feeling of dying and oppression, accompanied by sweating and nausea. When a patient is suspected of having a myocardial infarction, he can immediately chew up 300 mg of aspirin and call 120. At this time, chewing aspirin enteric-coated tablets can make the drug disintegrate quickly, accelerate the absorption of the drug, and make it play an anti-platelet role more quickly. In addition, before coronary stent surgery, you can also take chewing aspirin to play a quick role.

　　(Peng Wenxing is the pharmacist in charge of the Pharmaceutical Department of Beijing anzhen hospital affiliated to Capital Medical University.)

　　[Talking about health]

　　The doctor is kind. For a long time, the vast number of medical staff in our country have carried forward the spirit of respecting life, saving lives, being willing to contribute, and having boundless love, and serving the people’s health wholeheartedly. They have propped up the largest medical and health service system in the world, supporting the people’s healthy dreams. "Health depends on life" is the professional oath of every doctor, and it is also the reflection of their lofty medical ethics and selfless spirit.

Yang Xiaoling, a 37-year-old head nurse in the department of neonatology of the People’s Hospital of Inner Mongolia Autonomous Region, is nicknamed "Yang Yizhen". As long as she picks up the needle tube, no matter how small the blood vessel is, it can be "one needle in place". Over the past 18 years, Yang Xiaoling has cared for more than 30,000 children, successfully treated premature babies and critically ill newborns for many times, and won the 23rd "China Youth May 4th Medal". Xinhua news agency

　　The story behind the disease

　　Coming out of the "cool" operating room, I rushed to the noisy neurosurgery clinic, and the spacious corridor was full of patients waiting for treatment. The speech with different accents, the silence of the elderly, the noise of children and the colorful colors of summer clothes constitute the scene of outpatient service. Patients whose hair hasn’t grown out after craniotomy, for me, can’t bring a refreshing feeling, because the surgeon’s first reaction when he sees the knife edge is worry. "How did they recover after surgery?" These subconscious thoughts accompanied by rapid pace, I walked into the clinic.

　　"Please enter the consulting room for the patient of Derong on the 10th!" A young girl with dark skin, indifferent expression and straight eyes was led into the clinic by her family.

　　"Director zhao, do you remember me? You operated on my brother two years ago, and now that the family has enough money, we want to treat my sister again! " The patient’s younger brother said.

　　"How is your brother recovering?"

　　"Very good! He has stopped taking drugs, and epilepsy has never occurred. Now he is doing business with me in Lhasa. " "My sister’s illness, like my brother’s, is convulsing at intervals, and she makes it worse." The patient’s younger brother kept telling, while the elder sister still sat there with a straight face. However, the mother standing by was in tears: "Director Zhao, thank you for curing my eldest son. In fact, my family should have operated on my daughter a long time ago. On the one hand, it is really difficult economically, and I need to borrow money to make up for the operation expenses; On the other hand, the daughter has been married, and the husband’s family is four or five miles away from our village. The operation must also be approved by the man’s family. "

　　"Last month, I went to my daughter’s in-laws to discuss the operation. They didn’t agree to pay for the operation. I was very angry. When my daughter saw me coming, she kept dodging me. When I pulled her over, I found that my whole body was covered with blue and purple, and my right arm was swollen and deformed. I asked what happened, and her man said that my daughter fell when she was ill. I’ve seen my daughter when she’s sick. It won’t cause bruises all over her body at all. Did they hit you? The daughter nodded silently and muttered that she was going home. In a fit of pique, I brought my daughter home … …” Mother nagged, with endless words and full of grievances. The younger brother listened, his hands clasped the veins stood out, and his head bowed trembling and said, "I’m the only one at home who is not sick. I’ll treat my sister even if I sell blood to raise money."

　　Experience tells me that both brother and sister suffer from medial temporal lobe epilepsy, while familial temporal lobe epilepsy is rare. There was an Italian document that reported 15 cases of familial temporal lobe epilepsy, which was caused by genetic defects. Usually, patients had a history of febrile convulsions in newborns or children, and generally began to have seizures in their teens. With frequent onset, patients’ memory, learning ability and even living ability are seriously affected. Imaging examination of brain magnetic resonance can show atrophy and sclerosis of hippocampus (the hippocampus of normal people is closely related to higher nervous activity of emotion, learning and memory, so it is named because it looks like hippocampus). Eeg records can capture epileptic discharges, mostly from one or both hippocampus. Even if many patients take more than two kinds of antiepileptic drugs, they will have an average of 2 to 3 seizures every month, which is clinically called drug-refractory epilepsy. Such patients are suitable for preoperative evaluation to find the focus that causes epilepsy. Surgery is like shooting a target. If we can see and find ten ring’s bull’s-eye before surgery, plus the doctor’s surgical experience and skills, it is possible to get full marks, that is, the epilepsy symptoms disappear completely after surgery, and patients will no longer take drugs.

　　Derong soon moved into the ward, and the suffering brought by epilepsy to this family deeply touched me, making me chat with the patient’s mother and brother as much as possible after busy work to understand their inner feelings.

　　The Derong family comes from the rural area of Fuzhou, Jiangxi Province, where they mainly make a living by planting rice twice a year. Each person has one acre of land and can’t earn much money in one year. Now all the young people in the village have gone to work in other places, and the rest are old people and "left-behind children", as well as "patients" who can’t go out. Derong is one of them. As far as work is concerned, Derong never spares no effort, and her husband’s family cultivates several acres of land. Sometimes, bending over in the sun, working in the field, fatigue induced seizures, Derong suddenly ran around unconsciously, and the rice fields that had just been sorted out became a mess. Locally, epilepsy is called "sheep running crazy".

　　De Rong’s mother told me that in fact, she and her brother both developed normally when they were young. For some unknown reason, on the same day 20 years ago, both of them had a high fever at the same time, the highest temperature was 40 degrees Celsius, which lasted for three days, and what was more serious was a febrile convulsion. After a week of treatment in the local mine hospital, both brothers and sisters were out of danger, and since then, they have had seizures. Epilepsy changed their fate. My brother got married and got married and had a son. However, when the child was less than one year old, his daughter-in-law left him and the child and ran to other provinces. So far, there was no news. Because of this disease, Derong lowered the standard of marriage and married a man from a neighboring village with physical disabilities. As described above, he lived in a muddle with no head in sight.

　　The pillar of the family is actually the youngest son, Derong’s mother told me. The 29-year-old Deyi junior high school went to work in other places without graduation, and learned to do business. In the last three years, she went to Lhasa to do telecommunications business, that is, to sell mobile phones and accessories. I once asked him why he chose to do business in Lhasa. Is there any danger and can his body handle it? Deyi replied that people in Lhasa are very nice and simple, and more importantly, they can earn more money there to support their families and save money to see their brothers and sisters. Seeing my brother and sister have seizures since childhood has brought endless pain and confusion to young Deyi. Why did it happen in our house? Why do brothers and sisters all suffer from this disease? Will I twitch, too? A series of questions lingered in Deyi’s mind. Two years ago, my brother’s successful operation made him see hope. Now my brother is doing business with him in Lhasa and taking better care of his life.

　　Derong’s operation was successfully completed. Microscopically, clear brain structure and atrophied hippocampus can be seen, and the brain tissue is obviously harder than normal people. In fact, the anterior temporal lobe resection is familiar to me, but this time Derong’s operation has made me more careful, and there must be no complications, and the epilepsy must be removed. This idea has been lingering in my mind. Microscopically, it is not only the tortuous cerebral cortex and beating blood vessels that are magnified, but also the face of Zhang Derong’s family, anxious and expectant eyes and trust. After the operation, Derong’s spirit improved obviously, and his personality became like a different person, making it easier to communicate with others, and there was no seizure. The long-term effect needs further observation. Coincidentally, Derong’s surgical site is the same as his brother’s, both located in the right temporal lobe and hippocampus.

　　Brothers and sisters, who had febrile convulsions on the same day 20 years ago, suffered from the same epilepsy disease and underwent surgery at the same site. As an attending doctor, I am glad that I can do my best to eliminate the pain caused by the disease and help them experience the dignity and happiness of life again.

　　Behind every disease is a story that touches the heart. As a doctor, are you willing to take the time to understand and listen? Usually, doctors pay more attention to patients’ symptoms, but ignore patients’ personal psychology, family environment and social influence. Doctors should not only treat patients as diseased organs, but also care for the whole "person". Modern biology — Psychology — The medical model of society requires doctors to pay more attention to the influence of social and psychological factors on patients’ diseases, and medical care that embodies humanistic care is the core and essence of the whole treatment experience. In the whole process of diagnosis and treatment, patients give their experiences and emotions to doctors like gifts. We should cherish this trust, and the heart-to-heart communication between doctors and patients can give patients real comfort and hope.

　　I wish my brother and sister back home a speedy recovery! I sincerely hope that the crazy life caused by epilepsy will be calm and life will change from now on. After all, the power of love can call for the return of family ties.

　　(Author: Zhao Guoguang, Dean of xuanwu hospital, Capital Medical University)

　　Be a big doctor.

　　Looking back on my own growth process, I finished my undergraduate medical course with the first-class grant from the state because of my poor family in college, and then I finished my postgraduate study for three years with the salary of the state. Later, I was funded to study abroad twice by the state at work. It was the party and the state that trained me to be a big doctor. The oath that I took when I stood in party flag always inspired me, Do not forget your initiative mind, to be a soldier serving the people’s health.

　　With the change of lifestyle and the arrival of aging society, the incidence of chronic diseases such as cancer in China is increasing year by year, and will increase by two or three times in the next ten to twenty years, with seven new tumor patients every minute, which seriously affects the health and happiness of the people. Without national health, there will be no overall well-off society. We must attach importance to the prevention and control of major diseases, strengthen early screening and early detection, and promote early diagnosis and treatment.

　　At present, health and poverty alleviation have become an important mission for our doctors. As an oncologist in a large national third-class first-class hospital, I walked from a high consulting room to a remote village — — Taoquan Township, a region with the highest incidence of esophageal cancer in the world. With the national "Twelfth Five-Year" science and technology support program, we have carried out the research and promotion of key technologies for cancer screening and prevention in rural areas here, put forward new methods and means for screening and prevention of esophageal cancer in high-incidence areas, and established a demonstration base for cancer specialty in grass-roots hospitals.

　　In 2016, China-Japan Friendship Hospital took the lead in setting up a specialized medical association of integrated traditional Chinese and western medicine oncology in China, aiming at promoting the graded diagnosis and treatment of malignant tumors, improving the diagnosis and treatment level of specialized diseases, establishing a systematic and standardized talent training system for integrated traditional Chinese and western medicine oncologists, and promoting the development of disciplines. We have extended 20 oncology specialties of integrated traditional Chinese and western medicine to more than 300 hospitals, helped more than 30 county-level hospitals to set up oncology specialties, trained more than 10,000 oncology specialists, and improved the service ability of primary oncology specialties.

　　Learning at the grassroots level and constantly improving in practice, we have established a screening model for high-risk areas of esophageal cancer based on tongue images, and carried out research on the prevention of esophageal cancer by cooperation of Chinese and Western medicine; Combining the wisdom of "preventing diseases" of traditional Chinese medicine with modern artificial intelligence AI, the "Wangzhi" system of intelligent health of traditional Chinese medicine was developed to serve the health of the people more accurately and widely.

　　On the road of health and poverty alleviation, we have also passed through many old revolutionary areas, including Yudu in Jiangxi, Xishui in Guizhou and Dangchang in Gansu. While helping the old areas to build oncology specialties, we also feel the spirit of the Red Army’s Long March. When Mr. Chen Daowang translated the communist party Declaration, he tasted that "the taste of faith is sweet". Today, our efforts and hardships on the road of health and poverty alleviation are also substantial and beautiful.

　　　(Author: Jia Liqun, director of the Department of Oncology, China-Japan Friendship Hospital)

　　I can open your world.

　　Late at night, under the dim light, I turned on the computer and thought about what title to write this story with. Suddenly, my son knocked at the door and said, "mom, open the door." I, uh, was awakened.

　　What is "open"? There are many ways to "open". Open a box; Open a door and window; Open the door of wisdom; It can also be, open the door of the heart.

　　As an otolaryngology nurse, what I want to open up most is the silent world of deaf-mute patients. They can’t hear beautiful voices and say beautiful words, so they can only live in a silent world. It is no different from the appearance of ordinary people, but they can’t communicate like ordinary people, which causes confusion in their living conditions. Deaf-mute children are the most vulnerable deaf-mute groups. Deaf-mute children can’t feel the cheers of their parents when they are born. They can only look at the silent world with a pair of clear eyes and listen to their own voices quietly.

　　On that day, a little deaf patient came, as big as my daughter, with beautiful big eyes shining brightly and pigtails carefully combed on her head. Who would have thought that such a lovely baby, who was just one and a half years old, was a deaf-mute child?

　　Mother came to the nurse’s station with her baby in her arms and sat opposite me. I asked softly, "Does the child have a history of drug allergy?"

　　My mother looked at me blankly. When I repeated my question, she took the pen in my hand and wrote on the paper: "My father and I are both deaf and dumb".

　　Looking at this beautiful font, my heart was shocked. What a miserable family this is. She went on to write:

　　We can communicate on paper.

　　The mother’s smile is as beautiful as a flower, which makes me recover from the shock just now. "On paper" has become our way of communication. After I finished a series of in-hospital health education, they returned to the ward with my hospital gown prepared in advance.

　　It may be because the baby is as big as my daughter, or it may be because of this special family. I pay more attention to this patient. Although communication is more troublesome, I am still willing to share their worries during hospitalization and reduce their psychological burden.

　　After the child finished the operation, we affectionately called her "cochlear implant". Cochlear implant is an electronic device, which converts the sound into an electrical signal with a certain coding form by an in vitro language processor, and directly excites the auditory nerve through an implanted electrode system to restore or reconstruct the hearing function of the deaf. At present, cochlear implant has been used as a routine method to treat severe deafness to total deafness all over the world.

　　We are all distressed to see that the bald head of the "cochlear implant" is wrapped in thick gauze. She hobbled in the corridor wearing a small hospital gown, and her mother held a small hand with a big hand, inadvertently revealing the warmth of maternal love, and the angel’s heart would be melted by this warmth.

　　Accurate needle infusion, careful observation of postoperative wound conditions and illness changes, even when patrolling the ward at night, we should gently cover the PDA to prevent the dazzling light from waking the baby’s sleep, and all of them can’t bear to let her get a little hurt again. We are looking forward to and believe that in the near future, the baby will definitely call out to his mother affectionately, hold his mother’s hand and be alive and kicking.

　　When she was discharged from the hospital, Cochlea saw us waving to her, and she shook her hand and said goodbye to us. Looking at the distant figure in the corridor, I seem to see a pair of angel wings growing on her back, and I seem to see the breeze blowing the leaves and falling leisurely when the child grows up. She said to me, "Aunt, I can hear that voice, very light, very light."

　　At that time, I would still be wearing a white dress and a Dai Yan hat, shuttling between the ward and the corridor, repeating ordinary nursing work such as injection, medicine distribution, temperature measurement and blood pressure measurement.

　　As time goes by, the only thing that has changed is that the heavy responsibility of trusting each other’s lives has made me more and more awed by the sacred profession of "angels in white".

　　　(Author: Wang Jing, a nurse in charge of Otolaryngology Department of China-Japan Friendship Hospital)

Wen Miao Mirror Entertainment is written by Xiao Man and edited by Zhang Fengyi.

Experienced the epidemic in 2020, for any film and television company, it has experienced unprecedented difficulties.

After half a year’s closure, domestic cinemas ushered in a season of recovery, but the performance of the domestic film market, which has entered the Lunar New Year file cycle, is still tepid, and the daily box office remains at around 30 million.

Recently, the third quarter financial reports of 20 listed film and television companies have been disclosed. There were as many as 15 film and television companies that lost money in the first three quarters, of which WANDA CINEMAS lost as much as 2.015 billion, ranking first, while Huace Film and Television, which focuses on TV drama business, made a profit of 203 million yuan.

The fourth quarter and the Lunar New Year file are not only the last hope for companies to turn over their performance, but also the future and destiny of many film and television companies. If they lose money for two consecutive years, WANDA CINEMAS will be "ST" and Huayi Brothers will also face the risk of being delisted.

At this important schedule node, we don’t need to be "calm", but we are more eager to be "crowded".

According to the third quarterly report, WANDA CINEMAS achieved an operating income of 3.214 billion yuan and a net profit loss of 2.015 billion yuan in the first three quarters.

As WANDA CINEMAS suffered a huge loss of 4.729 billion yuan last year, it will be specially treated as a "ST share" according to the provisions of the Shenzhen Stock Exchange that "the net profit has been negative for two consecutive years". If Wanda can’t work miracles in the fourth quarter of this year, it may become a "ST WANDA CINEMAS".

At the critical moment, on the evening of November 9, WANDA CINEMAS released the Report on the Issuance of Non-public Offering of A Shares and the Listing Announcement, announcing that the total amount of funds raised reached 2.93 billion yuan, which was the first company in the film and television industry to complete the fixed increase this year and the largest fixed increase project in the history of A-share film and television industry.

The lock-up period of this fixed increase is 6 months, and Wanda will be used to build new cinemas, replenish the company’s working capital and repay funds. Affected by this news, it opened in the morning of November 10th, and WANDA CINEMAS once had a daily limit.

This year’s WANDA CINEMAS is a bad year, with few bright spots in the market business. The overseas cinema industry laid out many years ago has now become a huge drag.

In 2012, Wanda Group invested $2.6 billion to acquire 100% equity of AMC Entertainment, and WANDA CINEMAS became the largest cinema line operator in the world.

After many years, Wanda continued to adhere to the business philosophy of "Buy in buy buy". After successively acquiring cinemas such as Odeon, UCI and armike, AMC also became the largest cinema company in the United States.

When the epidemic struck, AMC’s once proud scale advantage suddenly became the company’s huge weakness.

At the beginning of this year, AMC announced the closure of 1,000 cinemas. Since then, it has fired a number of employees and launched a salary reduction plan for cinema executives. Even so, AMC has recently reported that funds are in a hurry. Some Wall Street analysts said that the bankruptcy of AMC is almost a foregone conclusion.

The situation in the American market is in dire straits, and domestic business is also difficult to do. Wanda currently has more than 600 cinemas in China. During the closure of the epidemic, the fixed costs of Wanda Studios such as depreciation, rent, employee compensation and financial expenses were high, which made its revenue performance suffer a great impact.

At the same time, in the film and television business sector, Wanda has not achieved outstanding results. Although there is a film jointly produced by The Sacrifice and WANDA CINEMAS, it is a drop in the bucket for WANDA CINEMAS, which suffered huge losses, given that the film has not reached the box office volume of 1 billion at present.

With Detective Chinatown 3’s announcement of the Spring Festival in 2021, it is almost announced that WANDA CINEMAS has completely abandoned this year’s film market.

In September, Wanda Film and Television Group released the annual film list for 2021-2022, and released more than 40 new film and television projects, such as Get My Brother Away 2, Searching for Dragons 2, Ghost Blowing the Lantern, Miskilling 2 and Seeing You, by Detective Chinatown 3 in one breath.

Wanda’s film and television business is betting on the next two years. This year’s Lunar New Year file has been abandoned. WANDA CINEMAS announced that its business will return to normal in the fourth quarter, but Wanda’s return to blood will be very limited in the case of a depressed market.

On August 21st, it was just one month since the cinema officially resumed work.

The Eight Hundred, which announced its withdrawal last year, was officially released on this day. In one fell swoop, the film broke the gloomy atmosphere of the market for a long time. At that time, under the condition of limiting the attendance rate by 30%, it eventually accumulated more than 3.1 billion and became the global box office champion in 2020.

The Eight Hundred not only boosted the confidence of the whole film market, but also gave Huayi Brothers in from the mire a shot in the arm.

As the first stock of film and television on the Growth Enterprise Market, Huayi Brothers lost 1.09 billion yuan and 3.96 billion yuan respectively in the past two years. If losses occur for three consecutive years, Huayi will also face the risk of delisting.

The crux of Huayi is not the continuous loss, but the lack of hope. After "Mobile Phone 2" and The Eight Hundred successively announced the withdrawal of files, Huayi’s hands are running out of cards. Tsui Hark’s "Four Kings of Di Renjie" was cold at the box office, while Xiaogang Feng’s Only Cloud Knows’s performance was mediocre, and the trump card was exhausted, but it still didn’t work, which made Huayi, who had been in the scenery, helpless and gradually marginalized.

Huayi Brothers’ third quarterly report shows that the company achieved operating income of 1.107 billion yuan, down 31.51% year-on-year, and net profit loss of 326 million yuan. It is worth mentioning that in the third quarter, Huayi achieved an operating income of 783 million yuan, up 45.02% year-on-year, which was mainly due to the nearly 600 million yuan of revenue from The Eight Hundred.

But at the same time, Huayi Brothers still suffered a loss of 94.563 million yuan in the third quarter, which was mainly affected by the non-recurring investment loss confirmed by the equity disposal of overseas joint venture company Brothers International LLC.

Looking at the performance in the first three quarters, Huayi’s main support point is still the film and television business, with revenue accounting for 89.88%. Brand authorization and live entertainment, which had made a high-profile March before, accounted for only 4.92%, and Internet entertainment accounted for 4.59%. However, in terms of film and television business, Huayi’s online dramas, such as Beggar with Nine Fingers, Kitchen with Fireworks, and Looking for Porcelain from Antique close encounter of mahjong, were all mediocre, which failed to cause market waves.

Obviously, there is only one The Eight Hundred, which can’t save Huayi, who is deeply mired in the mire.

Huayi also participated in the movie The Sacrifice, which, like Wanda, can bring very limited revenue. The Order to Serve the Gods produced by Huayi has been announced as the file for the Spring Festival in 2021. Since then, Lu Chuan’s "749 Bureau", Stephen Chow’s "Mermaid 2" and Xiaogang Feng’s "One Year in Spring" are all key projects of Huayi, and they can’t be missed.

In the past month, the share price of Light Media dropped from the highest of 16.66 yuan to 11.81 yuan, and its market value evaporated by about 14 billion yuan.

The data shows that the operating income of Light Media in the first three quarters was 481 million yuan, down 80.46% year-on-year; The net profit of returning to the mother was 63.7202 million yuan, down 94.26% year-on-year.

In the first three quarters of this year, the R&D expenses of Light Media increased by 61.16% compared with the same period of last year, and most of these funds were used in the animation production business of the company.

In 2015, Light established the striped house film industry, which specializes in the production of animated films. Ne Zha is the work that striped house has been pregnant for four years. The amazing box office of the film of 5.035 billion yuan made Light taste the sweetness for the first time, and it is reasonable for Light to continue to increase its animation business.

In 2012, "Sorry" made Light Media famous in World War I, and after many years of layout, Light finally ushered in a big explosion again, that is, the animated film Ne Zha released last summer.

As the box office in Ne Zha rises, the stock of Light Media also rises accordingly, even surpassing WANDA CINEMAS for a time, becoming the leader of film and television stocks. Until this year, the epidemic caused almost all major film companies to stop eating, but Light also made a small profit by developing derivatives of Nezha.

Because there are no heavy assets such as cinemas and cinemas, the light media, which travels lightly, can still make a small profit, although its revenue has fallen sharply. Ray’s revenue mainly comes from the movie Sheep Without A Shepherd, the derivative development of the movie Ne Zha in the first half of the year, and The Eight Hundred’s Buckwheat Grows Wild and My Girlfriend is a Robot, etc., which are all released by Ray’s participation or agency.

At the same time, the revenue of Legend of Deification, whose National Day box office exceeded 1.5 billion yuan, has not been included in the first three quarters, but according to the current market performance of Legend of Deification, the revenue that this film can bring to the light is about 400 million yuan.

At the end of Legend of Deification’s film, the light also released the eggs of the next film "Deep Sea". In addition, animated films such as "Big Fish Begonia 2" and "Journey to the West" are also ready to meet the audience.

In the three quarterly reports of film and television companies, Huace Film and Television has the most outstanding performance.

In the first three quarters, Huace achieved a total revenue of 1.894 billion yuan, up 44.60% year-on-year, and the net profit attributable to shareholders of listed companies was 203 million yuan, up 736.72% year-on-year.

As an old film and television company, Huace’s annual drama output ranks first in film and television companies for many years, and there are often explosions.

This year’s Huace has a costume romance drama "Beautiful South Song", an urban workplace drama "Ordinary Glory", and "In the Name of Family" with the theme of healing youth growth, with diverse types and good market response.

In terms of reserved projects to be broadcast, many plays, including "8090", "Dear, Beloved", "You are my city camp", "Mirror Twin Cities" and The Legend of Fei, have entered various platforms and TV programs.

In terms of movies, Huace film and television also has an important layout, not only participated in the recent popular movie The Sacrifice, but also the movie A Writer’s Odyssey, which is mainly directed by Huace, will be released in the Spring Festival next year.

In the context of the huge impact on the film market, Huace Film and Television, the main drama series, went upstream and handed over a stable answer sheet. Although this is not surprising, it is also a rare surprise.

After a huge loss of 2.306 billion yuan in 2019, Beijing culture was hit again in the first three quarters of 2020, and various businesses fell across the board.

The financial report shows that in the first three quarters of 2020, Beijing Culture realized an operating income of only RMB 13 million, a year-on-year decrease of 98.15%, and a net profit loss of RMB 117 million. At the same time of the decline in performance, the capital chain of Beijing Culture also tightened. The company’s asset-liability ratio rose from 24.22% in 2018 to 52.81% in the third quarter of this year.

Up to now, My People My Homeland, a film controlled by Beijing culture, has closed at the box office of 2.762 billion yuan, which is expected to turn the final performance of Beijing culture into a profit.

On the unilateral side of the film to be screened, Bath Buddy produced by Beiwen has announced the final file on December 11th, "Hello! Li Huanying is scheduled for the Spring Festival in 2021, and the series "Fengshen", with a total investment of nearly 3 billion, will also officially meet the audience next year.

Backed by the powerful background resources of Hunan Radio and Television, Mango Hypermedia often staged the magical drama of "making small and big".

According to the financial report, Mango Supermedia achieved operating income of 9.471 billion yuan in the first three quarters, up 15.05% year-on-year, and net profit attributable to shareholders of listed companies was 1.612 billion yuan, up 65.39% year-on-year.

The biggest advantage of mango hypermedia, which focuses on self-made content, lies in low-cost investment. No matter whether it is drama series or variety show, it can always harvest unexpected surprises. This year’s fire variety "Sister Riding the Wind and Waves" has helped the stock of Mango Hypermedia to soar to a new level with a market value of hundreds of billions. The next stop is happiness, in the name of my family, dear myself, glass and other dramas are also hot works with high topics, which has greatly increased the revenue of Mango TV.

Since then, Mango has also released a brand-new "Monsoon Plan" short theater in terms of incubating potential variety shows such as "Sister Braving the Wind and Waves 2" and "Brother with Thorns", and plans to build a total of ten short plays with 12 episodes per season.

In the first three quarters of 2020, Wentou Holdings achieved a revenue of 282 million yuan, a decrease of 80.64% compared with the same period of last year. The net loss attributable to shareholders of listed companies was 788 million yuan, and the net profit decreased by 1,860.57% year-on-year.

Wentou Holdings said in the third quarterly report that the company’s operating income in the first three quarters decreased by 80.64% year-on-year, mainly due to the impact of the COVID-19 epidemic, the cinema was suspended from late January to mid-July, resulting in a significant decrease in revenue during the reporting period compared with the same period last year.

By September 30, 2020, Hengdian film and television had a total of 70,300 screens in China. In the first three quarters, the total box office of China film market was 7.563 billion yuan, a decrease of 84.20% compared with the same period of last year, which made Hengdian film and television revenue drop sharply.

After the cinema resumed work, Hengdian Film and Television continued to increase the layout of the cinema industry. In the third quarter, 16 new cinemas were opened and 102 new screens were added. In the first three quarters of this year, Hengdian Film and Television achieved an operating income of 399 million yuan, a year-on-year decrease of 81.27%, and a net loss attributable to shareholders of listed companies was 368 million yuan.

Jinyi Film and Television, which also specializes in cinema, also suffered a decline in performance. In the first three quarters of 2020, its revenue was about 220 million yuan, down 85.90% year-on-year. The net loss was about 406 million yuan, a year-on-year decrease of 487.33%.

In the first three quarters, Ciwen Media’s main revenue items included Trident, Thunder in the Restarted Sea, Chance of Winning and The Voice of Chinese Dreams Our Songs. Due to poor market performance, its revenue dropped sharply.

Ciwen Media achieved operating income of 338 million yuan in the first three quarters, down 60.28% year-on-year. The net profit attributable to shareholders of listed companies was 18.2825 million yuan, compared with 89.8912 million yuan in the same period last year.

In the first three quarters, Hualu Baina achieved an operating income of 73.633 million yuan, a year-on-year decrease of 84.53%, and the net profit attributable to shareholders of listed companies was 35.0971 million yuan, a year-on-year decrease of 61.53%.

Regarding the reason for the decrease in operating income compared with the previous period, Hualu Baina said that it was mainly due to the delay in the project progress during the reporting period and the decrease in repertoire income compared with the same period of last year.

Huanrui Century’s revenue in the first three quarters of 2020 was only 17.19 million yuan, a year-on-year decrease of 87.49%; The net loss was about 148 million yuan, a year-on-year decrease of 2716.26%.

Huanrui Century said that the decrease in revenue was mainly due to the decrease in drama series of some broadcast projects and the impact of the project cycle. The company’s film and television drama sales revenue and artist brokerage income decreased significantly compared with the same period of last year.

In 2018, it lost 927 million yuan, and in 2019, it lost 1.007 billion yuan. If it can’t make a profit for three consecutive years, Tang De Film and Television will be in danger of being directly delisted. Nowadays, Tang De film and television, which is dragged down by Ba Qing Chuan, is exhausted. In the first three quarters, the operating income was 170 million yuan, and the net loss attributable to shareholders of listed companies was 83.7 million yuan.

In the first three quarters, Happiness Blue Sea Cucumber invested in works such as Stewed Sydney with Rock Sugar, Trident, Children in the Bay Area and Happiness Will Knock on the Door, but it is difficult to have a decisive impact on the company’s revenue. In the first three quarters of 2020, Happiness Blue Ocean realized a total operating income of 217 million yuan, a year-on-year decrease of 84.5%, and the net profit attributable to shareholders of listed companies was a loss of 275 million yuan, a year-on-year decrease of 673.66%.

Since the cinema officially resumed work, the film and television market has shown obvious signs of recovery, and explosive works have appeared from big screen to small screen. As the first important financial report after the cinema resumed work, the third quarterly report of the film and television company has a very important weathervane significance for the current market performance and future trend.

Judging from the overall financial report, film and television companies are basically in the post-traumatic recovery period. If film and television companies in the post-cold winter era want to get back on track, it is essential to continuously output high-quality works. Whether it is to boost theater attendance or create topics to boost revenue, the principle of "content is king" will not change.

If winter comes, can spring be far behind? After the most difficult period, the next performance of the film and television market is worth looking forward to.

　　Pepper originated in South America, and was brought back to Europe after Columbus discovery of america in the late 15th century, and was introduced to China in the late Ming Dynasty.

　　Nowadays, peppers can be seen everywhere in our lives, also known as chili pepper, Spicy Horn, Sea Pepper, Pepper, Qin Pepper, etc. They can be eaten directly as vegetables, and can also be used as spices for seasoning various dishes. Sichuan, Hunan, Guizhou, Yunnan, Jiangxi and other provinces in China are all famous "no spicy, no happy" areas.

　　In addition to raw or fried food, Chili powder, Chili oil, Chili sauce, chopped pepper and pickled pepper made of Chili are also popular ways to eat. Different varieties of pepper can present different colors, with red being the most common. The common varieties in China are Xiaomi pepper, Erjingtiao, Horn pepper, Horn pepper, Morning pepper, Lantern pepper and so on.

　　How much do you know about "spicy" nutrition?

　　1. vitamin c

　　Speaking of the nutrition of pepper, the most commendable thing is its rich vitamin C, which is a leader in the vegetable industry.

　　Green pepper contains 62 mg of vitamin C in 100 g, while small red pepper contains 144 mg of vitamin C in 100 g, which is 7 times that of tomatoes and 4 times that of oranges.

　　Needless to say, the benefits of vitamin C have long been deeply rooted in people’s hearts.

　　2. Carotene

　　Carotene in pepper is also rich, which helps to maintain the health of eyes and skin.

　　3. Other nutrients

　　In addition, small peppers also contain B vitamins, vitamin E, potassium, magnesium, iron, zinc, selenium and other nutrients.

　　4. Capsaicin

　　Pepper is not only rich in nutrition, but also contains a unique class of active substances — — Capsaicin, that is, the spicy ingredient in pepper.

　　A large number of studies show that capsaicin has many physiological functions, including stimulating appetite and promoting digestion; Protect gastric mucosa, prevent and treat gastric ulcer; Promote fat metabolism, reduce fat and lose weight; Analgesia, diminishing inflammation and relieving itching; Dispel wind and dampness, and protect joint health; Lowering blood pressure and cholesterol and protecting cardiovascular system; Anti-cancer and so on.

　　With the function of capsaicin being gradually recognized, natural capsaicin and synthetic capsaicin extracted from pepper have become an important by-product of pepper and are widely used in food industry and medical field.

　　How to "Surrender" the King of Vitamin C

　　Pepper is a wonderful vegetable. People who love it are all hot and unhappy, and those who hate it avoid it. For those who can eat spicy food and love spicy food, pepper must be a frequent visitor at the table, but they may not eat spicy food.

　　Why do you say that? As mentioned earlier, pepper is the king of vitamin C, but vitamin C is very unstable. If the cooking method is unreasonable, it will be easily destroyed. Therefore, it is not enough to say that the content is high, and it is the last word to eat it in the stomach.

　　In order to destroy vitamin C in pepper as little as possible, raw food is a good choice. If you want to stir-fry, it is best to stir-fry quickly.

　　Many people like to eat Chili products such as Chili sauce and Chili oil. This way of eating spicy food not only greatly reduces vitamins, but also easily ingests excessive salt, which is not healthy and should not be eaten more.

　　After all, not everyone can enjoy the spicy pepper. What about people who can’t eat spicy pepper?

　　In fact, when making cold salad, you can completely replace some peppers with sweet peppers. The content of capsaicin in sweet pepper is less, but the content of vitamin C and carotene is no less than that of pepper, and the colorful pepper can make people happy, especially for children, which is helpful to encourage them to eat more vegetables. (Text/Director of the Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Ma Guansheng)

Huasheng Online September 13 th (all-media reporter Tian Tian trainee reporter,
Zeng Guanlin) A man in Changsha suddenly fell to the ground while playing football, and his heart stopped. Three seconds after falling to the ground, the referee immediately suspended the game; 1 minute and 23 seconds, Yuan Biao, deputy director of the emergency department and deputy chief physician of Changsha Central Hospital, participated in the competition and performed cardiopulmonary resuscitation on the spot; At 3 minutes and 02 seconds, the teammate took the AED first aid equipment from the customer service center; In July 25 seconds, the players who fell to the ground regained consciousness, breathing and heartbeat, and the rescue was successful. He was only one step away from death, but now everything is normal.

On September 8, a relay rescue about life was staged in Changsha. A group of Changsha men successfully beat the god of death in 7 minutes and 25 seconds. Behind the thrilling is the double guarantee of first aid knowledge and first aid equipment.

Today, Yuan Biao received pennants and flowers from the families of the rescued players.

Thrilling for 7 minutes, textbook rescue creates miracles.

"Thank you! Without you, our family would be ruined. " This morning, Yuan Biao, who was busy in Changsha Central Hospital, was held tightly by the families of the rescued team members. Having been a doctor for many years, it is his duty to save lives. Unexpectedly, outside the ward, excellent first aid skills also helped him successfully save a fresh life.

On September 8, it was the match day of Yuan Biao’s OAK football team. Although it is only an amateur team composed of owners in Yuelu District and Yanghu District, everyone pays special attention to the game, and specially invited professional referees and photographers, and every player is ready.

At 20: 30 that night, about 60 minutes after the start of the game, in the midfield where the ball was being passed fiercely, suddenly a player slipped to the ground holding his knee. The sound of hitting the ground quickly caught the attention of teammates around.

In the third second after the players fell to the ground, the referee blew the whistle urgently and suspended the game.

In 12 seconds, the captain called for help, and more teammates heard the sound, including Yuan Biao. "At that time, I went forward to check the situation, and I couldn’t feel my breathing and pulse." Captain Wang’s first reaction was that his teammate might have a cardiac arrest. He immediately opened his mouth, tried his best to keep the respiratory tract unobstructed, and asked other teammates to call 120.

In 20 seconds, the teammate dialed 120 emergency calls. After the call was dialed, 120 emergency personnel kept talking to guide the on-site rescue.

In 30 seconds, the teammates dispersed, and many people took off their clothes to serve as fans for those who fell to the ground.

In 56 seconds, the team members quickly went to the customer service center of Yanghu Sports Park to get AED first aid equipment. "This instrument is an indispensable artifact in the first aid of cardiac arrest." Yuan Biao introduced that once cardiac arrest occurs, 4 minutes is the golden rescue time, and then the survival rate decreases by 10% every minute. After more than 10 minutes, the survival rate is almost zero. "Every minute and every second of us is racing against death."

At 1 minute and 23 seconds, Yuan Biao started cardiopulmonary resuscitation.

At 3 minutes and 02 seconds, the AED was in place, and the hope of life increased by one point. Because cardiopulmonary resuscitation requires a lot of physical strength, Yuan Biao, who has been exercising for a long time and has been rescuing, is obviously exhausted and sweaty. Seeing that his physical strength was in a hurry, his teammates began to shout around the stadium, "Is there anyone who can give first aid, please help to save people …" Ren Ruolan, a doctor of rehabilitation medicine and physiotherapy of Hunan Armed Police Corps Hospital, was doing frisbee exercise nearby.

3 minutes and 52 seconds, Ren Ruolan took part in the first aid relay.

On June 28th, an electric shock was given to a teammate who fell to the ground with AED emergency equipment.

At 7 minutes and 17 seconds, a miracle appeared. The teammates who had never had independent consciousness before recovered their weak consciousness.

In July 25 seconds, the teammates who fell to the ground regained consciousness, breathing and heartbeat, and the rescue was successful.

At 15 minutes and 05 seconds, the ambulance arrived and watched the teammates who fell to the ground be carried into the ambulance. Someone at the place breathed a sigh of relief. Whether familiar or strangers, excitedly high-five, everyone knows that they have won this fight with death.

Behind the miracle is the double guarantee of first aid knowledge and equipment.

"I never think miracles can happen at any time. We should learn from them." Yuan Biao said that in recent years, with the popularization of first aid knowledge, more and more people began to know the importance of first aid knowledge, but they still lacked experience and needed more simulation practice.

"There is also the need to equip public places with AEDs." According to Yuan Biao, as early as 2019, the Basic Medical Care and Health Promotion Law of People’s Republic of China (PRC) made it clear that public places should be equipped with necessary first-aid equipment and facilities such as automatic external defibrillator (AED) according to regulations to improve the efficiency of pre-hospital first aid. At present, many public places in Changsha are equipped with first aid equipment, but many citizens don’t know about it, let alone use it.

What needs to be paid attention to is that many people think that sudden death generally occurs in the elderly, but in recent years, sudden death has occurred in young and middle-aged people, especially those aged 35 to 50. There are many reasons for sudden death, which are not very clear, but the inducing factors such as hypertension, diabetes and other basic diseases, smoking, alcoholism, obesity, irregular life, stress and staying up late may also lead to sudden death. It is recommended to have regular physical examinations and pay attention to physical health.

Yuan Biao reminded that when doing strenuous exercise, you must do what you can. When you feel that your physical strength is in a hurry, you must stop and rest, and don’t overload your exercise.

Link:

What you need to know about sudden death from sports.

Sports sudden death refers to non-traumatic accidental death that occurs during exercise or within 24 hours after exercise. Exercise is not the main cause of sudden death, but the hidden heart disease is the "behind-the-scenes" of sudden death caused by exercise. Sudden death can be divided into cardiogenic and non-cardiogenic. Cardiogenic refers to the onset of cardiovascular diseases, of which coronary heart disease is the most common. Non-cardiogenic factors include overwork, alcoholism, taking drugs, strenuous exercise and so on.

Stay away from danger during exercise, and pay attention to the following points:

1. Check risks before exercise: Conduct regular physical examination, especially cardiovascular system examination, to check potential disease threats.

2. Ensure adequate warm-up: Warm-up before exercise can make as much blood flow to the heart, lungs and muscles as possible, improve the metabolic capacity of the heart and lungs, and ensure that the energy metabolism of the human body can meet the needs of exercise after entering high-intensity exercise.

3, exercise should not be overloaded: when exercising, do what you can, feel physical emergency or physical discomfort, be sure to stop and rest, do not overload exercise.

4. Replenish energy in time: sports drinks, energy bars and salt pills should be replenished in time for long-term or intense exercise.

5, sick and unwell, do not exercise: cold and fever make the body’s immune ability decline, and it is not recommended to exercise vigorously when you are very tired and stay up late.

6. Don’t stop immediately after exercise: Don’t stop immediately after exercise and give your body a buffer time. You can do some static stretching actions together, and don’t take a shower immediately, drink a lot of ice drinks, blow air or blow air conditioning.

What is an AED?

AED is the abbreviation of external automatic defibrillator. It is a medical device with a computer, which can evaluate the patient’s heart rhythm and transmit electric shock to the heart when the rhythm time of electric shock is detected.

Ventricular fibrillation is a disorderly activity of the patient’s cardiac electrophysiological system (this state can occur in atrium or ventricle). When it occurs in the ventricle, it will vibrate in a rapid and disorderly way, preventing the ventricle from pumping blood to the whole body. AED can remove ventricular fibrillation by electric shock and make the heart return to normal work. Patients with cardiac arrest have the greatest chance of survival if they perform cardiopulmonary resuscitation immediately and use AED within a few minutes.

(First trial: Huang Juan, second trial: Peng Zhiguo, third trial: Zhou Wenbo)